It is confusing being out here trying to interpret all the good info coming from a few Substack authors that I subscribed to, including yours. I've been trying a form of this protocol through an online clinic, and I haven't have much success yet fighting my metastatic prostate cancer. I been implementing the protocol in one form or another since late August. I was doing the protocol 7 days a week, then went to 5 on 2 off. I have read about the importance of Pulsing. Today I read another article about it is easy to make mistakes in taking the pills at the wrong time. My question is what would be the best protocol for prostate cancer that has been in my bones since 2023, and is continuing to progress pretty rapidly. I would like the know the times of the day to take each pill, and whether to take it with food or not and what type of food is best. Even though I feel I am on the right track, and I take the right meds I think I may be implementing the protocol the wrong way. I also think I may add chemo, which I did in 2024, and start taking ADT again that I stopped in may 2025. Your thoughts would be really appreciated.
I have tried to keep it as simple as possible. Start with the metabolic trap as the foundation; it blocks the 5 major pathways. The add on from there. Keep it simple. Should only need to take meds twice a day. Don’t follow multiple “experts”; too many cooks spoil the broth.
Oh, gosh, Tony, I am with you on this, but from the TNBC angle. First I’m told to do this, then that, then I read substacks that tell me that what everyone else says (including online clinics) is wrong. What is a cancer patient to do??? Sometimes (lately, most of the time) I’m thinking that ignorance truly iS bliss…. sigh
My wife had TNBC in 2013. She went the conventional route like most people back then. She did Chemo first, then radiation and then a quadrantectomy. 11 years later she is still in remission. She has neuropathy and treatments were tough but she did well. It sucks that after all this money spent on research the mainstream offers nothing that isn’t toxic.
Tony, I did the “conventional” thing, too, starting last year. Lumpectomy, mastectomy, chemo, radiation…. and also alongside that I’ve been following a repurposed drug protocol right from the start. I know the “aggressive, spreads easily” trait of TNBC, so throwing everything that I can against it. But I am happy to hear your wife is doing well after all this time! There is hope! Alas, peripheral neuropathy, though. I’ve got that, too, and while I’m doing OK with it, I suspect it never really goes away completely.
I have tried to keep it as simple as possible. Start with the metabolic trap as the foundation; it blocks the 5 major pathways. The add on from there. Keep it simple. Should only need to take meds twice a day. Don’t follow multiple “experts”; too many cooks spoil the broth.
I’m with you Tony. We were doing everything all at once. Then I just read about pulsing. Then I read that an all at once is better for high grade. I read Mebendazole is best for Glioblastoma. Then I read rotating between that and FenBen is better to avoid adaptation.
You are correct... I have a protocol for Lymphoma in general.. but need to do one for Hodgkin's Lymphoma specifically .. although have to acknowledge that the standard care achieves good results. But I would always add adjunctive care.
yes, you are correct. I will fix this. Yes. In fact, hormone receptor-positive (ER+/PR+) breast cancers appear to be among the breast cancer subtypes with the strongest links to lipid metabolism, although this dependence is complex and evolves during disease progression.
Any recommended protocol for individuals that have managed to beat cancer (adenocarcinoma in a removed polyp) relative to maintenance to prevent recurrence? Most protocols deal with active cancer; few discuss maintenance after clearance of the cancer.
Janne. YES. I have a few post coming on what to do once ned. I am out of town right now. If you e-mail me next week I can send the protocols. pmarik@protonmail.com
This is a useful framing. The part that stood out to me is the distinction between tumor shrinkage and durable control. It makes the metabolic question feel less like “which fuel?” and more like “how many escape routes remain open?”
I just found (and now subscribe) to your wonderful and insightful column and have had Hairy Cell Leukemia since 1999 with sadly many re-occurrences. It's a subset of CLL. Seeing your statement about Axis 5 being most important for CLL, wouldn't Quercetin also be an effective tool since it is anti-inflammatory and supposed to reduce cytokines (IL-6)?
Reduce sugar, moderately reduce fats.. still need energy to survive. Using the cancer blocking agents. .. block cancer cells in preference to normal cells
It is confusing being out here trying to interpret all the good info coming from a few Substack authors that I subscribed to, including yours. I've been trying a form of this protocol through an online clinic, and I haven't have much success yet fighting my metastatic prostate cancer. I been implementing the protocol in one form or another since late August. I was doing the protocol 7 days a week, then went to 5 on 2 off. I have read about the importance of Pulsing. Today I read another article about it is easy to make mistakes in taking the pills at the wrong time. My question is what would be the best protocol for prostate cancer that has been in my bones since 2023, and is continuing to progress pretty rapidly. I would like the know the times of the day to take each pill, and whether to take it with food or not and what type of food is best. Even though I feel I am on the right track, and I take the right meds I think I may be implementing the protocol the wrong way. I also think I may add chemo, which I did in 2024, and start taking ADT again that I stopped in may 2025. Your thoughts would be really appreciated.
I have tried to keep it as simple as possible. Start with the metabolic trap as the foundation; it blocks the 5 major pathways. The add on from there. Keep it simple. Should only need to take meds twice a day. Don’t follow multiple “experts”; too many cooks spoil the broth.
Oh, gosh, Tony, I am with you on this, but from the TNBC angle. First I’m told to do this, then that, then I read substacks that tell me that what everyone else says (including online clinics) is wrong. What is a cancer patient to do??? Sometimes (lately, most of the time) I’m thinking that ignorance truly iS bliss…. sigh
My wife had TNBC in 2013. She went the conventional route like most people back then. She did Chemo first, then radiation and then a quadrantectomy. 11 years later she is still in remission. She has neuropathy and treatments were tough but she did well. It sucks that after all this money spent on research the mainstream offers nothing that isn’t toxic.
Tony, I did the “conventional” thing, too, starting last year. Lumpectomy, mastectomy, chemo, radiation…. and also alongside that I’ve been following a repurposed drug protocol right from the start. I know the “aggressive, spreads easily” trait of TNBC, so throwing everything that I can against it. But I am happy to hear your wife is doing well after all this time! There is hope! Alas, peripheral neuropathy, though. I’ve got that, too, and while I’m doing OK with it, I suspect it never really goes away completely.
@Jo Lynne Yes there is hope and my thoughts and prayers are with you! Keep up the good fight!
I have tried to keep it as simple as possible. Start with the metabolic trap as the foundation; it blocks the 5 major pathways. The add on from there. Keep it simple. Should only need to take meds twice a day. Don’t follow multiple “experts”; too many cooks spoil the broth.
I’m with you Tony. We were doing everything all at once. Then I just read about pulsing. Then I read that an all at once is better for high grade. I read Mebendazole is best for Glioblastoma. Then I read rotating between that and FenBen is better to avoid adaptation.
It is all so confusing.
Sorry to hear about your metastatic Prostate cancer
https://geoffpain.substack.com/p/prostate-cancer-caused-by-endotoxin
Radiation is being pushed
https://geoffpain.substack.com/p/pluvicto-177-lutetium-radiation-therapy
as is BioNTech mRNA treatment for Prostate Cancer
https://geoffpain.substack.com/p/klk2-gene-of-the-day-involved-in
Hello Tony, is it OK to private-message you?
Hi Noa, could you private message me too? My father is somewhat in the same boat as Tony…we would appreciate any information we can get. Thank you!
yes
Great. Will do, later on today.
You are correct... I have a protocol for Lymphoma in general.. but need to do one for Hodgkin's Lymphoma specifically .. although have to acknowledge that the standard care achieves good results. But I would always add adjunctive care.
yes, you are correct. I will fix this. Yes. In fact, hormone receptor-positive (ER+/PR+) breast cancers appear to be among the breast cancer subtypes with the strongest links to lipid metabolism, although this dependence is complex and evolves during disease progression.
Any recommended protocol for individuals that have managed to beat cancer (adenocarcinoma in a removed polyp) relative to maintenance to prevent recurrence? Most protocols deal with active cancer; few discuss maintenance after clearance of the cancer.
Janne. YES. I have a few post coming on what to do once ned. I am out of town right now. If you e-mail me next week I can send the protocols. pmarik@protonmail.com
This is a useful framing. The part that stood out to me is the distinction between tumor shrinkage and durable control. It makes the metabolic question feel less like “which fuel?” and more like “how many escape routes remain open?”
I just found (and now subscribe) to your wonderful and insightful column and have had Hairy Cell Leukemia since 1999 with sadly many re-occurrences. It's a subset of CLL. Seeing your statement about Axis 5 being most important for CLL, wouldn't Quercetin also be an effective tool since it is anti-inflammatory and supposed to reduce cytokines (IL-6)?
Yes. Good thought.
So how can glioblastoma be treated to stop FAO?
Please see my posts on the metabolic trap and the Approach to treating cancer
I’ve read it. It doesn’t really tell how to stop FAO. Blocking pathways doesn’t seem to do it.
The only way is to interrupt the pathway. Multiple agents do this. See most recent post. Paul
Love it! What a great way to understand the biology of cells! Thank you
Dearest Doctor. I am trying to upgrade my subscription so I may seek your advice about possible throar cancer but unable to
Noddy. I dont quite understand the issue. I am out of town at the moment. you can e-mail me at pmarik@protonmail.com
Thankyou very much for responding. My name is Georgina. I will make contact when I have more test results. God Bless You😇
So not only reduce sugar but also fat , my friend's oncologist said she must put on 5 kg to help sustain chemo therapy - how does she do it , thanks
Reduce sugar, moderately reduce fats.. still need energy to survive. Using the cancer blocking agents. .. block cancer cells in preference to normal cells
Thank you for this article! 🙏 What about triple positive BC?
Nope. Only TNB cancer
What about hodgkins/lymphoma? I cant find a protocol for it for some reason
Doctor I thought hormone driven breast cancer also liked fatty?