And by the way, the number one way to induce cancer, reliably and particularly in experimental mice and rats is to give them vaccination after vaccination! Something to think about huh?
Pulmonary fibrosis is a very serious disease. There are drugs that have been developed specifically for this disease. You need to consult a pulmonologist. This is out of my area of expertise.
For a very good reason. He uses toxic doses of drugs (we see all the patients who develop severe toxicity) and his results are not credible. The have not been published. Please stick to the science.
I dont want to engage in an argument with him.... its a pointless exercise. . He has viciously attached Dr. Kory and myself on his sub stack. He uses a different approach to us.
I really like that medicine made from the soil life (as ivermectin is) and other medicines made from plants have more of a shot-gun approach rather than the highly engineered single molecules which almost by definition stimulate biological ways around them.
Ivermectin has been a main stay for me in cattle practice over the years, but I only use it if clinically needed (not scheduled blanket treatments).
Thanks for a very comprehensive review, but I find it strange that whenever I see information about the success of Ivermectin in treating cancers, there is never any mention of Dr. William Makis from Canada who has pioneered this treatment and has helped thousands of patients with cancer to achieve successful outcomes. Credit should be given where credit is due. Dr. Makis is about to open a cancer clinic in Florida where he will treat all kinds of cancer, not only with Ivermectin, but with other repurposed drugs as well as some conventional oncologic remedies. I wish him great success and finally some acknowledgement for his tireless efforts in treating cancer patients.
I will not comment in detail. Dr Makis is not truthful and has been indicted on multiple crimes prior to the COVID pandemic… including sexual harassment. The dosages he suggests are insane… we see the complications his treatment causes.
Dr Marik - Thank you for your accurate appraisal of “Dr” Makis. It has been very concerning to me that so many are of the persuasion that he is a “medical professional” to follow, to promote & to praise.
I am in the field of education, not medicine, and was taught as early as 5 yrs of age to be willing to question things & statements, etc by my amazing common-sense, engineering-minded Dad & the old-school practicality of my mom. (They in actuality “lived” out their Christian faith). I was blessed.
Perhaps those are factors that caused me to question & ultimately be thoroughly disgusted by the charlatan, Makis.
My first intro on the other hand to you, your brilliance, knowledge, ongoing expertise & compassion was in the televised conference that Senator Ron Johnson had relatively early on in the covid-era mess. You were & are a Godsend.
I am not able to adequately thank you here for your talks, writings, research, etc …but, please know that I thank you from the bottom of my socks - all the way from my heart!
No. Dr. William (Viliam) Makis was not accused of or charged with sexual misconduct in Alberta.
Confusion regarding this topic often stems from a 2019 College of Physicians & Surgeons of Alberta (CPSA) publication that reported on disciplinary actions alongside a general regulatory update regarding provincial sexual misconduct legislation (Bill 21).
No. Dr. William (Viliam) Makis was not accused of or charged with sexual misconduct in Alberta.
Confusion regarding this topic often stems from a 2019 College of Physicians & Surgeons of Alberta (CPSA) publication that reported on disciplinary actions alongside a general regulatory update regarding provincial sexual misconduct legislation (Bill 21).
Claire - when you pull back the curtain - you will eventually see that Makis is his own biggest fan & self-promoter. One can do Facebook groups & Substacks, and interviews, & “borrow” info & protocols from others & make it appear it is theirs. And market themselves to such a point that national media types take notice & do interviews, but that does not mean they & their manipulations pass the smell test. I hope you understand that to which I am referring.
In a world where the pharmaceutical industry prioritizes its financial welfare over the welfare of the patient, disingenuously peddling toxic substance to supposedly alleviate suffering and improve outcomes, how refreshing it is to find a promoter of Hippocratic ideals of doing no harm while safely furthering cures and remissions of this most feared disease.
Thank you Dr. Marik for your unmatched integrity and commitment to the welfare of your patients. It is because of people like you that we will win this war.
you and many others are quite high on the ketogenic diet. I am not. I find cancer can eat anything. If you starve it of carbohydrates, it will eat proteins and fatty acids. There's no question about that. At least a hundred studies show this.
There's also a big trend now all about the 'zoles and the Ivermectins of the world. They are okay. What I often see with these case studies is a tumors shrunk, but very few people are actually completely NED, no evidence of disease.
But there has been and is a much more effective solution that works, I believe, in around 80% of cancers to get rid of them within a month or so oftentimes, or at least within six months.
These people go from cancers riddling their body to no evidence of disease, in my experience most of the time.
I'm talking about very high dose cannabinoids, especially THC, which can be administered through rectal depositories so that it doesn't have psychogenic effects. It reaches the entire lymphatic system and the entire body quite rapidly.
Two resources. https://cannabishealthradio.com/ It contains hundreds of interviews of people that have beaten cancer with cannabinoids.
And my own modest contribution. I've had over 80,000 students I've coached. Many of them have had cancer, not a majority but many. And although I can't really track all the results, my anecdotal evidence shows this to be very effective indeed.
Thank you for your comments. There is overwhelming evidence that diet alter the outcome of cancer. There is no doubt about this.. see my posts on this topic. This is even published in the oncology peer reviewed literature. Guy Tenebaum’s book describes how he cured his widely metastatic cancer with diet alone. You are correct cancer are metabolically flexible; thats the reason I came up with the 5-axis approach (the metabolic trap) that block s the major pathways. You can find this as a post on my website. As for cannabis I have reviewed this extensively while it is good for pain control and nausea etc it has minimal anti-cancer activist. This is a post in the que (to come later). Paul
I don’t disagree with the use of THC as one method of treating cancer. But as a cancer patient who has read a lot about cancer and various treatments, as well as observing fellow cancer patient journeys, cancer is a sneaky beast and what works for one doesn’t mean it will work for everyone. Keto works for some, Mediterranean diet works for others. Chemo, cannabis and alt treatments (ivermectin and zoles) all have helped some but not all. People have different DNAs. Some have other conditions (diabetes, high blood pressure, etc) that affect what treatments may work. All we can do is listen to our bodies, try the method that makes sense to us, switch if it’s not working, and hope for NED. Having read various medical viewpoints, as well as traditional oncology, everyone agrees eating a healthy diet and exercise are very important in helping our bodies.
I've just watched your video, cannabis oil without doubt is the most potent of all the anticancer substances used in the alternative realm, and your advice on how to use it was informative for those that haven't a clue. I used it this way on a woman over 13 years ago 8 cm tumour in the lung, she smoked all the way through the treatment which included chemotherapy and radiation, cured her in 3 months, that was a gram per day in a divided dose morning and night mixed 50/50 with coconut oil, delivered rectally via 5 ml syringe just beyond the sphincter. She stayed on the oil for over two years a rice grain size taken orally before bed.
A little over 12 months later the same protocol on a man with an aggressive prostate cancer with a small pelvic bone intrusion that was done in a hospital with radiation the prostate was healed in 3 months. They are both alive today. He also continued it orally like the woman did for more than 2 years. No chemo used or radiation on the prostate.
In February 25 a gentleman contacted me about a relation with non small cell lung cancer, we had a long conversation and I recommended fenbendazole and ivermectin as his primary substances he also included Metformin, atorvastatin, and low dose naltrexone minerals and vitamins. It took until late September for her all clear. The reason I recommended this protocol was cost, I assured him if it failed I'd get the cannabis and make the oil. Worth mentioning is it worked slower than cannabis, for 4 months or more there was no shrinkage but there was no growth either, then the tumour started to collapse. Remember that if you are using ivermectin and fenbendazole.
I should mention to you that ivermectin the liquid form can like cannabis oil be taken rectally where like cannabis oil it absorbs from the lower colon to the lymphatic system, fenbendazole must be taken orally.
Cancer is simply a fungal disease and any substance that has an effect on it is without exception antifungal, can you or anyone name a substance that wasn't antifungal in nature ? I've been looking for near 20 years and haven't found one. Of great significance is ivermectin, fenbendazole/mebendazole and cannabis oil work the same way as microtubule disruptors not of your cells or the cancerous cells but the malassezia fungi within the cancerous cells in addition soursop, Curcumin, wormwood and ashwaggandha all work in the same way which is unique insofar as near all other antifungal substances work by effecting the cell wall of the fungi and many of those work extremely well and should be used with the above mentioned. Liked your video by the way.
I have found cheap ways to get cannabis in quantities needed for cancer. From US$30 /gram of oil to US$5 or so. Makes it affordable for most people. Medicare also recently announced that they are going to pay some cannabis costs now, which will be very helpful.
I find that the ‘zoles and ivermectin are slower, and I would always recommend cannabis instead.
One would have to assume the five dollar oil would be made from leaf. I'm interested to know if you have used leaf oil or know anyone that has used it successfully. I've used it orally and it's extremely powerful and seems as strong as the oil from buds.
no it’s flower oil. It’s just that there is super cheap THCA full spectrum today and simply decarboxylating it by slow cooking in the oven turns it into the oil you need to use.
One of the best ways to support someone with cancer is to provide food that doesn’t fuel the cancer. Medical schools are standardized on purpose by the corporations that fund them. Med students are on purpose not even taught that sugar is what fuels cancer. We’ve known this for a 100 years. https://wavesandpositions.substack.com/p/they-knew-cancer-ate-sugar-they-gave
Hi Paul, thanks for the thoughtful read on ivermectin and its potential as an anti-cancer therapeutic. For the sake of patients, I sincerely hope that ivermectin proves effective at reducing cancer disease burden. According to http://ClinicalTrials.gov, ivermectin in the intervention in a currently recruiting trial for metastatic triple-negative breast cancer (mTNBC).
I think that we (collectively) need to temper our expectations and think about the potential of ivermectin rationally. Ivermectin binds with high affinity to glutamate-gated chloride channels. These channels do not exist in humans - but are highly expressed in the parasites for which ivermectin is typically prescribed. Ivermectin, will bind (with lower affinity - requiring a higher potentially toxic dose) to P2X4 purinergic receptors, GABA(A) receptors, and glycine receptors.
Unfortunately, none of these low-affinity human targets play a causal role in cancer. It is true that ivermectin can kill cancer cells in vitro (in a petri dish), and some studies have even shown it to be effective at reducing tumor burden in immune compromised animal models (I’ve written about this previously). The doses used - when translated to humans - would be systemically toxic; its unknown if its toxicity to the cancer cells is greater than its toxicity to otherwise healthy cells. I think it is important to remember that these drugs go into people; we don’t want to kill the patient in order to eliminate the cancer.
I think it is good to let the science speak on whether this drug will be efficacious. I’m looking forward to reading the outcome of the currently enrolling study.
Cully, D., Vassilatis, D., Liu, K. et al. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature371, 707–711 (1994). https://doi.org/10.1038/371707a0
Hibbs, R., Gouaux, E. Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature474, 54–60 (2011). https://doi.org/10.1038/nature10139
Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA. Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci. 1999 Sep 1;19(17):7289-99. doi: 10.1523/JNEUROSCI.19-17-07289.1999. PMID: 10460235; PMCID: PMC6782529.
Ménez C, Sutra JF, Prichard R, Lespine A. Relative neurotoxicity of ivermectin and moxidectin in Mdr1ab (-/-) mice and effects on mammalian GABA(A) channel activity. PLoS Negl Trop Dis. 2012;6(11):e1883. doi: 10.1371/journal.pntd.0001883. Epub 2012 Nov 1. PMID: 23133688; PMCID: PMC3486876.
Estrada-Mondragon A, Lynch JW. Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors. Front Mol Neurosci. 2015 Sep 25;8:55. doi: 10.3389/fnmol.2015.00055. PMID: 26441518; PMCID: PMC4585179.
Lynagh T, Webb TI, Dixon CL, Cromer BA, Lynch JW. Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel. J Biol Chem. 2011 Dec 23;286(51):43913-43924. doi: 10.1074/jbc.M111.262634. Epub 2011 Oct 27. PMID: 22033924; PMCID: PMC3243547.
Thanks for your comments. I have seen Ivermectin melt away tumors with my own eyes. RCTS are near impossible to perform for a host of reasons. Time will tell. The science is not settled. You should also be arguing against the enormously expensive and toxic chemotherapy agents which have largely been proven to have minimal effect on extending life expectancy (3.4 months).
Another blind spot of the standard testing methods is their need to reduce the number of variables in order to tell a convincing story. Are they considering the role of light in the bedroom? There is research showing that those women that blocked light had a significantly lower level of breast cancer relapse while on the drug under study. Are they considering the beneficial effects of ivermectin on the gut microbiome? Are they considering lifestyle choices that reduce or drive inflammation? Standard trails would collapse under their own weight if they tried to quantify all the real inputs to their patient’s health outcomes.
Yes, it is true that the science is not settled, but it is also not in ivermectin’s favor. Its high affinity target simply does not exist in humans. Its lower affinity targets (the ones that are expressed in humans) do not play a causal role in cancer. RCTs are not impossible - they are very difficult -, thousands of clinical trials are actively recruiting patients. The challenge (sometimes referred to as the 4 Rs) is to identify the right target, the right tissue, the right patient, with the right safety profile. Get these 4 right, and you have an effective treatment - for that individual. Cancer is not a monolithic disease, but rather a constellation of diseases - even within a single patient. Within a single tumor there may be multiple types of cancer cells, each of which is susceptible to a different therapeutic agent. And yes, it is extraordinarily difficult to identify these 4 Rs for a given patient with respect to the repertoire of available therapeutics.
If I’m arguing for anything, it is a rational, data-based assessment of a compound’s safety and efficacy at treating disease.
A constellation of diseases my arse. It's a fungal disease in nearly all its forms, we even know the culprit the dimorphic lipophilic yeast malassezia. Google pancreatic cancer and malassezia Aykut et al then google cancer and malassezia straussman. Then return to the thread with your constellation of refutations.
And to add insult to injury many of the same doctors who were pushing high-dose ivermectin were also pushing supplements, which are PGP inhibitors, which make it very difficult for your body to get rid of ivermectin, therefore building up in your system at higher and higher levels without you Even knowing it . this was not an accident. Dr. McCullough and his wellness company should be taken to task for this. They need to explain themselves.
I had ivermectin prescribed for some lingering symptoms of COVID in 2021, and I definitely experienced visual disturbances.
It was like an acid trip without the altered mental state.
I can't remember the lag time in onset of symptoms, but it got to the point where I had to time my dose so I knew I wouldn't be driving or working when it kicked in.
And by the way, the number one way to induce cancer, reliably and particularly in experimental mice and rats is to give them vaccination after vaccination! Something to think about huh?
Agree
Pulmonary fibrosis is a very serious disease. There are drugs that have been developed specifically for this disease. You need to consult a pulmonologist. This is out of my area of expertise.
Interrsting, what are the side effects? Is it required long term or does it actually benefit and 'fix' the issue?
Paul, this is an amazing review! Thanks for providing it!
Thanks.. my friend
For a very good reason. He uses toxic doses of drugs (we see all the patients who develop severe toxicity) and his results are not credible. The have not been published. Please stick to the science.
I dont want to engage in an argument with him.... its a pointless exercise. . He has viciously attached Dr. Kory and myself on his sub stack. He uses a different approach to us.
Thank you
I really like that medicine made from the soil life (as ivermectin is) and other medicines made from plants have more of a shot-gun approach rather than the highly engineered single molecules which almost by definition stimulate biological ways around them.
Ivermectin has been a main stay for me in cattle practice over the years, but I only use it if clinically needed (not scheduled blanket treatments).
Thanks for a very comprehensive review, but I find it strange that whenever I see information about the success of Ivermectin in treating cancers, there is never any mention of Dr. William Makis from Canada who has pioneered this treatment and has helped thousands of patients with cancer to achieve successful outcomes. Credit should be given where credit is due. Dr. Makis is about to open a cancer clinic in Florida where he will treat all kinds of cancer, not only with Ivermectin, but with other repurposed drugs as well as some conventional oncologic remedies. I wish him great success and finally some acknowledgement for his tireless efforts in treating cancer patients.
I will not comment in detail. Dr Makis is not truthful and has been indicted on multiple crimes prior to the COVID pandemic… including sexual harassment. The dosages he suggests are insane… we see the complications his treatment causes.
Dr Marik - Thank you for your accurate appraisal of “Dr” Makis. It has been very concerning to me that so many are of the persuasion that he is a “medical professional” to follow, to promote & to praise.
I am in the field of education, not medicine, and was taught as early as 5 yrs of age to be willing to question things & statements, etc by my amazing common-sense, engineering-minded Dad & the old-school practicality of my mom. (They in actuality “lived” out their Christian faith). I was blessed.
Perhaps those are factors that caused me to question & ultimately be thoroughly disgusted by the charlatan, Makis.
My first intro on the other hand to you, your brilliance, knowledge, ongoing expertise & compassion was in the televised conference that Senator Ron Johnson had relatively early on in the covid-era mess. You were & are a Godsend.
I am not able to adequately thank you here for your talks, writings, research, etc …but, please know that I thank you from the bottom of my socks - all the way from my heart!
❤️💔❤️🩹
Don’t think he’s been actually “indicted” but thanks for this additional info regarding his recommended dosages.
Review the official legal documents in the province of Alberta Canada; he has been indicted for many crimes including sexual harrasment.
Oh my! Will look that up, thank-you.
No. Dr. William (Viliam) Makis was not accused of or charged with sexual misconduct in Alberta.
Confusion regarding this topic often stems from a 2019 College of Physicians & Surgeons of Alberta (CPSA) publication that reported on disciplinary actions alongside a general regulatory update regarding provincial sexual misconduct legislation (Bill 21).
No. Dr. William (Viliam) Makis was not accused of or charged with sexual misconduct in Alberta.
Confusion regarding this topic often stems from a 2019 College of Physicians & Surgeons of Alberta (CPSA) publication that reported on disciplinary actions alongside a general regulatory update regarding provincial sexual misconduct legislation (Bill 21).
indicted by whom?
Oh wow!
Thank you for your very kind words. They are greatly appreciated. I hate to criticize a “colleague”; however the truth must be told.
Claire - when you pull back the curtain - you will eventually see that Makis is his own biggest fan & self-promoter. One can do Facebook groups & Substacks, and interviews, & “borrow” info & protocols from others & make it appear it is theirs. And market themselves to such a point that national media types take notice & do interviews, but that does not mean they & their manipulations pass the smell test. I hope you understand that to which I am referring.
Thank you for all of your great information. Would you think ivermectin/fenbendazole be useful in multiple myeloma?
Yes… See approach to repurposed drugs,.. covers multiple myeloma
The doc is talking nonsense. Ivermectin is not liver toxic.
In a world where the pharmaceutical industry prioritizes its financial welfare over the welfare of the patient, disingenuously peddling toxic substance to supposedly alleviate suffering and improve outcomes, how refreshing it is to find a promoter of Hippocratic ideals of doing no harm while safely furthering cures and remissions of this most feared disease.
Thank you Dr. Marik for your unmatched integrity and commitment to the welfare of your patients. It is because of people like you that we will win this war.
Thanks. Appreciate you comment and support. I am trying my best.
you and many others are quite high on the ketogenic diet. I am not. I find cancer can eat anything. If you starve it of carbohydrates, it will eat proteins and fatty acids. There's no question about that. At least a hundred studies show this.
There's also a big trend now all about the 'zoles and the Ivermectins of the world. They are okay. What I often see with these case studies is a tumors shrunk, but very few people are actually completely NED, no evidence of disease.
But there has been and is a much more effective solution that works, I believe, in around 80% of cancers to get rid of them within a month or so oftentimes, or at least within six months.
These people go from cancers riddling their body to no evidence of disease, in my experience most of the time.
I'm talking about very high dose cannabinoids, especially THC, which can be administered through rectal depositories so that it doesn't have psychogenic effects. It reaches the entire lymphatic system and the entire body quite rapidly.
Two resources. https://cannabishealthradio.com/ It contains hundreds of interviews of people that have beaten cancer with cannabinoids.
And my own modest contribution. I've had over 80,000 students I've coached. Many of them have had cancer, not a majority but many. And although I can't really track all the results, my anecdotal evidence shows this to be very effective indeed.
https://mattcook.substack.com/p/how-i-would-get-rid-of-cancer-if
Thank you for your comments. There is overwhelming evidence that diet alter the outcome of cancer. There is no doubt about this.. see my posts on this topic. This is even published in the oncology peer reviewed literature. Guy Tenebaum’s book describes how he cured his widely metastatic cancer with diet alone. You are correct cancer are metabolically flexible; thats the reason I came up with the 5-axis approach (the metabolic trap) that block s the major pathways. You can find this as a post on my website. As for cannabis I have reviewed this extensively while it is good for pain control and nausea etc it has minimal anti-cancer activist. This is a post in the que (to come later). Paul
See today post on Ivermectin
I don’t disagree with the use of THC as one method of treating cancer. But as a cancer patient who has read a lot about cancer and various treatments, as well as observing fellow cancer patient journeys, cancer is a sneaky beast and what works for one doesn’t mean it will work for everyone. Keto works for some, Mediterranean diet works for others. Chemo, cannabis and alt treatments (ivermectin and zoles) all have helped some but not all. People have different DNAs. Some have other conditions (diabetes, high blood pressure, etc) that affect what treatments may work. All we can do is listen to our bodies, try the method that makes sense to us, switch if it’s not working, and hope for NED. Having read various medical viewpoints, as well as traditional oncology, everyone agrees eating a healthy diet and exercise are very important in helping our bodies.
I've just watched your video, cannabis oil without doubt is the most potent of all the anticancer substances used in the alternative realm, and your advice on how to use it was informative for those that haven't a clue. I used it this way on a woman over 13 years ago 8 cm tumour in the lung, she smoked all the way through the treatment which included chemotherapy and radiation, cured her in 3 months, that was a gram per day in a divided dose morning and night mixed 50/50 with coconut oil, delivered rectally via 5 ml syringe just beyond the sphincter. She stayed on the oil for over two years a rice grain size taken orally before bed.
A little over 12 months later the same protocol on a man with an aggressive prostate cancer with a small pelvic bone intrusion that was done in a hospital with radiation the prostate was healed in 3 months. They are both alive today. He also continued it orally like the woman did for more than 2 years. No chemo used or radiation on the prostate.
In February 25 a gentleman contacted me about a relation with non small cell lung cancer, we had a long conversation and I recommended fenbendazole and ivermectin as his primary substances he also included Metformin, atorvastatin, and low dose naltrexone minerals and vitamins. It took until late September for her all clear. The reason I recommended this protocol was cost, I assured him if it failed I'd get the cannabis and make the oil. Worth mentioning is it worked slower than cannabis, for 4 months or more there was no shrinkage but there was no growth either, then the tumour started to collapse. Remember that if you are using ivermectin and fenbendazole.
I should mention to you that ivermectin the liquid form can like cannabis oil be taken rectally where like cannabis oil it absorbs from the lower colon to the lymphatic system, fenbendazole must be taken orally.
Cancer is simply a fungal disease and any substance that has an effect on it is without exception antifungal, can you or anyone name a substance that wasn't antifungal in nature ? I've been looking for near 20 years and haven't found one. Of great significance is ivermectin, fenbendazole/mebendazole and cannabis oil work the same way as microtubule disruptors not of your cells or the cancerous cells but the malassezia fungi within the cancerous cells in addition soursop, Curcumin, wormwood and ashwaggandha all work in the same way which is unique insofar as near all other antifungal substances work by effecting the cell wall of the fungi and many of those work extremely well and should be used with the above mentioned. Liked your video by the way.
thank you for your wonderful stories.
I have found cheap ways to get cannabis in quantities needed for cancer. From US$30 /gram of oil to US$5 or so. Makes it affordable for most people. Medicare also recently announced that they are going to pay some cannabis costs now, which will be very helpful.
I find that the ‘zoles and ivermectin are slower, and I would always recommend cannabis instead.
Thanks for this.
One would have to assume the five dollar oil would be made from leaf. I'm interested to know if you have used leaf oil or know anyone that has used it successfully. I've used it orally and it's extremely powerful and seems as strong as the oil from buds.
no it’s flower oil. It’s just that there is super cheap THCA full spectrum today and simply decarboxylating it by slow cooking in the oven turns it into the oil you need to use.
I agree with adding the wonderful benefits of the cannabis plant when implementing any healing protocol. 💚💚
If chloroquine reduced the anti-cancer effects of Ivermectin then they shouldn't be taken together as is sometimes recommended. Is that right?
I think that is correct.
Are you referring to hydroxychloroquine?
2nd Smartest Guy in the World points to a study that shows synergy between chloroquine and Ivermectin.
https://ar.iiarjournals.org/content/45/11/4791
One of the best ways to support someone with cancer is to provide food that doesn’t fuel the cancer. Medical schools are standardized on purpose by the corporations that fund them. Med students are on purpose not even taught that sugar is what fuels cancer. We’ve known this for a 100 years. https://wavesandpositions.substack.com/p/they-knew-cancer-ate-sugar-they-gave
Hi Paul, thanks for the thoughtful read on ivermectin and its potential as an anti-cancer therapeutic. For the sake of patients, I sincerely hope that ivermectin proves effective at reducing cancer disease burden. According to http://ClinicalTrials.gov, ivermectin in the intervention in a currently recruiting trial for metastatic triple-negative breast cancer (mTNBC).
I think that we (collectively) need to temper our expectations and think about the potential of ivermectin rationally. Ivermectin binds with high affinity to glutamate-gated chloride channels. These channels do not exist in humans - but are highly expressed in the parasites for which ivermectin is typically prescribed. Ivermectin, will bind (with lower affinity - requiring a higher potentially toxic dose) to P2X4 purinergic receptors, GABA(A) receptors, and glycine receptors.
Unfortunately, none of these low-affinity human targets play a causal role in cancer. It is true that ivermectin can kill cancer cells in vitro (in a petri dish), and some studies have even shown it to be effective at reducing tumor burden in immune compromised animal models (I’ve written about this previously). The doses used - when translated to humans - would be systemically toxic; its unknown if its toxicity to the cancer cells is greater than its toxicity to otherwise healthy cells. I think it is important to remember that these drugs go into people; we don’t want to kill the patient in order to eliminate the cancer.
I think it is good to let the science speak on whether this drug will be efficacious. I’m looking forward to reading the outcome of the currently enrolling study.
Cully, D., Vassilatis, D., Liu, K. et al. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature371, 707–711 (1994). https://doi.org/10.1038/371707a0
Hibbs, R., Gouaux, E. Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature474, 54–60 (2011). https://doi.org/10.1038/nature10139
Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA. Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci. 1999 Sep 1;19(17):7289-99. doi: 10.1523/JNEUROSCI.19-17-07289.1999. PMID: 10460235; PMCID: PMC6782529.
Ménez C, Sutra JF, Prichard R, Lespine A. Relative neurotoxicity of ivermectin and moxidectin in Mdr1ab (-/-) mice and effects on mammalian GABA(A) channel activity. PLoS Negl Trop Dis. 2012;6(11):e1883. doi: 10.1371/journal.pntd.0001883. Epub 2012 Nov 1. PMID: 23133688; PMCID: PMC3486876.
Estrada-Mondragon A, Lynch JW. Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors. Front Mol Neurosci. 2015 Sep 25;8:55. doi: 10.3389/fnmol.2015.00055. PMID: 26441518; PMCID: PMC4585179.
Lynagh T, Webb TI, Dixon CL, Cromer BA, Lynch JW. Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel. J Biol Chem. 2011 Dec 23;286(51):43913-43924. doi: 10.1074/jbc.M111.262634. Epub 2011 Oct 27. PMID: 22033924; PMCID: PMC3243547.
Thanks for your comments. I have seen Ivermectin melt away tumors with my own eyes. RCTS are near impossible to perform for a host of reasons. Time will tell. The science is not settled. You should also be arguing against the enormously expensive and toxic chemotherapy agents which have largely been proven to have minimal effect on extending life expectancy (3.4 months).
Another blind spot of the standard testing methods is their need to reduce the number of variables in order to tell a convincing story. Are they considering the role of light in the bedroom? There is research showing that those women that blocked light had a significantly lower level of breast cancer relapse while on the drug under study. Are they considering the beneficial effects of ivermectin on the gut microbiome? Are they considering lifestyle choices that reduce or drive inflammation? Standard trails would collapse under their own weight if they tried to quantify all the real inputs to their patient’s health outcomes.
Yes, it is true that the science is not settled, but it is also not in ivermectin’s favor. Its high affinity target simply does not exist in humans. Its lower affinity targets (the ones that are expressed in humans) do not play a causal role in cancer. RCTs are not impossible - they are very difficult -, thousands of clinical trials are actively recruiting patients. The challenge (sometimes referred to as the 4 Rs) is to identify the right target, the right tissue, the right patient, with the right safety profile. Get these 4 right, and you have an effective treatment - for that individual. Cancer is not a monolithic disease, but rather a constellation of diseases - even within a single patient. Within a single tumor there may be multiple types of cancer cells, each of which is susceptible to a different therapeutic agent. And yes, it is extraordinarily difficult to identify these 4 Rs for a given patient with respect to the repertoire of available therapeutics.
If I’m arguing for anything, it is a rational, data-based assessment of a compound’s safety and efficacy at treating disease.
A constellation of diseases my arse. It's a fungal disease in nearly all its forms, we even know the culprit the dimorphic lipophilic yeast malassezia. Google pancreatic cancer and malassezia Aykut et al then google cancer and malassezia straussman. Then return to the thread with your constellation of refutations.
Thanks…
Chemo alone has a bad habit of killing the patient in an effort to eliminate the cancer.
And to add insult to injury many of the same doctors who were pushing high-dose ivermectin were also pushing supplements, which are PGP inhibitors, which make it very difficult for your body to get rid of ivermectin, therefore building up in your system at higher and higher levels without you Even knowing it . this was not an accident. Dr. McCullough and his wellness company should be taken to task for this. They need to explain themselves.
Agree
We use a binder,Quicksilver, foot detox with Epsom +, & sauna to minimize system build up toxins/loose particles. 2yrs, seems to be effective
I had ivermectin prescribed for some lingering symptoms of COVID in 2021, and I definitely experienced visual disturbances.
It was like an acid trip without the altered mental state.
I can't remember the lag time in onset of symptoms, but it got to the point where I had to time my dose so I knew I wouldn't be driving or working when it kicked in.
My dose wasn't even that high.