Neuroendocrine prostate cancer is an aggressive, treatment-resistant form of prostate cancer that often emerges after prolonged pressure from androgen deprivation therapy and androgen receptor–targeted drugs.
When I study the cellular mechanisms of malignancy, there is an overlap of the Covid jab’s mechanistic processes as well . So disturbing to say the least 😡
Dave. Because I took a stand with the COVID fiasco, i have had ALL my medical credentials removed/revoked and I am unable to see patients… I do not have a license to practice medicine. I am considered a misinformationist and a distributor of misinformation . However, I will help you as best I can. Its not a formal medical consultation however I can give you information that can help you make medical decisions. I am not able to change. My only source of income is this substack; so if you contribute it helps me survive. Paul
Hi Paul, can’t seem to see your other comment but I was the t cell lymphoma case. You mention in one of your blogs that Triglycerides/HDL ratios etc should be viewed as a cancer market, what’s the actual ratio to calculate / track so I can apply it on my blood tests?. I’m 4 months post chemo in remission and seem to have low insulin but normal glucose (am on metformin etc), IGF1 higher than what would like but working on it, rest seems largely stable, blood counts not yet recovered
Dr Marik, I'm in the process of reading your two latest posts on prostate cancer, as you recommended.
I'm stumped by what I see as inconsistency, but maybe I'm missing something. Can you please reconcile these two for me:
1 "Antibiotics cause severe dysbiosis which is associated with an increased risk of cancer and reduced response to chemotherapy" (Umbekoming, quoting your "Cancer Care" protocol)
2 you also say that doxycycline is one of the 5 pillars of attacking cancer ("inhibits mitochondrial ribosomes and oxidative phosphorylation, targeting cancer stem metabolism"), therefore needed in the fight against it.
I'm confused and really hope you'll respond. Thank you!
Doxycycline is a narrow spectrum antibiotic and has a minimal effect on the microbiome… and by rotating the overall effect on the microbiome is negligible.
What I find fascinating is that the observational side of your model increasingly describes the organism as adaptive, dynamic, and reorganizing under pressure — which makes a great deal of sense to me.
At the same time, I find myself wondering whether the proposed interventions fully align with the nature of the adaptive processes being described, or whether they still reflect a more constraint-oriented framework layered onto an increasingly systems-oriented understanding.
Given that cancers effect on cellular operation is not a forward "adaptation" change but a reverse adaptation to a time before our cells used oxygen, then to reverse the adaptation and perhaps get the cancer cells to re evolve back to normal seems possible..
That’s an interesting way of looking at it. I’ve been wondering something similar — whether at least part of what we call cancer reflects an adaptive survival-state shift within the organism rather than simply random malfunction.
What I find increasingly fascinating is not just the metabolic behavior of the tumor itself, but what may be happening systemically that allows those shifts in cellular behavior to emerge and persist in the first place.
When I study the cellular mechanisms of malignancy, there is an overlap of the Covid jab’s mechanistic processes as well . So disturbing to say the least 😡
Yes, this is coming in an upcoming post.
Thank you ☺️
Do you have a chart that simply shows the 5 axis metabolic interventions for patients to follow?
I once tried keto for 3 months, psa dropped by 30%! At 4 months it was back to original level, seemed like clear adaptation so i stoped.
The TG/HDL ration is a marker of insulin sensitivity and the metabolic syndrome. TG/HDL Ratio Interpretation
<1.0Excellent insulin sensitivity
1–2Good/metabolically healthy
2–3Mild insulin resistance concern
>3Significant insulin resistance likely
>4–5Severe metabolic dysfunction/high cardio metabolic risk
YES… see my post on the metabolic trap https://paulmarik.substack.com/p/the-metabolic-trap
HI Paul do you provide (paid) consults?
Dave. Because I took a stand with the COVID fiasco, i have had ALL my medical credentials removed/revoked and I am unable to see patients… I do not have a license to practice medicine. I am considered a misinformationist and a distributor of misinformation . However, I will help you as best I can. Its not a formal medical consultation however I can give you information that can help you make medical decisions. I am not able to change. My only source of income is this substack; so if you contribute it helps me survive. Paul
You can contact me at my e-mail address: pmarik@protonmail.com
Yes. See my post on the metabolic trap
Hi Paul, can’t seem to see your other comment but I was the t cell lymphoma case. You mention in one of your blogs that Triglycerides/HDL ratios etc should be viewed as a cancer market, what’s the actual ratio to calculate / track so I can apply it on my blood tests?. I’m 4 months post chemo in remission and seem to have low insulin but normal glucose (am on metformin etc), IGF1 higher than what would like but working on it, rest seems largely stable, blood counts not yet recovered
Dr Marik, I'm in the process of reading your two latest posts on prostate cancer, as you recommended.
I'm stumped by what I see as inconsistency, but maybe I'm missing something. Can you please reconcile these two for me:
1 "Antibiotics cause severe dysbiosis which is associated with an increased risk of cancer and reduced response to chemotherapy" (Umbekoming, quoting your "Cancer Care" protocol)
2 you also say that doxycycline is one of the 5 pillars of attacking cancer ("inhibits mitochondrial ribosomes and oxidative phosphorylation, targeting cancer stem metabolism"), therefore needed in the fight against it.
I'm confused and really hope you'll respond. Thank you!
Doxycycline is a narrow spectrum antibiotic and has a minimal effect on the microbiome… and by rotating the overall effect on the microbiome is negligible.
What I find fascinating is that the observational side of your model increasingly describes the organism as adaptive, dynamic, and reorganizing under pressure — which makes a great deal of sense to me.
At the same time, I find myself wondering whether the proposed interventions fully align with the nature of the adaptive processes being described, or whether they still reflect a more constraint-oriented framework layered onto an increasingly systems-oriented understanding.
Agree..
Given that cancers effect on cellular operation is not a forward "adaptation" change but a reverse adaptation to a time before our cells used oxygen, then to reverse the adaptation and perhaps get the cancer cells to re evolve back to normal seems possible..
That’s an interesting way of looking at it. I’ve been wondering something similar — whether at least part of what we call cancer reflects an adaptive survival-state shift within the organism rather than simply random malfunction.
What I find increasingly fascinating is not just the metabolic behavior of the tumor itself, but what may be happening systemically that allows those shifts in cellular behavior to emerge and persist in the first place.