Might be worth asking your doctor if propanol would be effective for your heart condition instead of metoprolol. I took metoprolol for a while for blood pressure but discontinued on my own when my heart rate was routinely falling below 50 at night.
One question: Would metoprolol provide the same protective effect? It's a selective beta-blocker (beta-one blocker) rather than a non-selective blocker like propranolol. I ask because I'm on high doses of metoprolol for a heart condition, so adding propranolol doesn't sound like a good idea for me. Oh, and my bp is usually in the high 80s/mid 40s range, so even less of a good idea to add propranolol...
Propranolol almost sounds like a miracle drug - but what do you do if it causes severe headaches and further drops in blood pressure for a person with already permanently low blood pressure... Is there any medication of similar profile and effect, perhaps?
That's ridiculous; "Keep doing everything stressful, then take a pill to block signaling." That's like processing out nutrients from cereal, then adding them back to fortify the cereal.
And you did not define stress. People blame chronic stress for everything but skip over the definition; "the physiological or psychological response of the brain and body to any internal or external demand, challenge, or threat".
That's the definition of Life. Seems unlikely that we have a more stressful life than our ancestors. Did they have pills back then?
Oh if your solution were only as easy as it sounds…. Sometimes people…All people…get stuck in terrible circumstances beyond their power to change (think Covid insanity/lockdown) and the result is “Stress”… not usual stress but the kind created by demons and “enforced” by their useful idiots in media and politics! Then again Millions die from stress induced heart attacks, strokes, and cancer every year…. If a beta blocker can help someone through a stressful period then thats ok as long as its not addictive or toxic! The Chinese have a few very good herbal formulas which have been around for centuries which are specific for stress! Xiao Yao Wan is the classic and its over 1000 years old!!
Great work! Growing research suggests that stress-related pathways, including beta-adrenergic signaling, may influence processes such as inflammation, angiogenesis, immune function, and tumor progression, making this an important area of ongoing investigation. At the same time, it’s important to remind ourselves that promising biological mechanisms do not automatically translate into established clinical practice. While propranolol and other beta-blockers have shown intriguing findings in preclinical studies and some observational research, their role as adjunctive cancer therapies remains under active investigation. Larger, well-designed randomized clinical trials are needed before they can be routinely recommended for this purpose outside of established indications. Perhaps one of the most exciting developments in oncology is the growing recognition that cancer is influenced not only by the tumor itself but also by the broader physiological environment in which it exists. Understanding how the nervous system, immune system, and metabolism interact with cancer biology may ultimately lead to more comprehensive and personalized treatment strategies. Thanks for sharing this insightful overview.
This makes complete sense to me as a person taking metoprolol for one of the listed medical reasons and also as a registered nurse, this makes complete sense that this Rx would have a positive effect on lessening the risk of cancer. There definitely is an anti-anxiety component to this medication and of course that makes sense that that has a positive effect. Thank you you. I appreciate having this document!
I'm doing the research for my best friend, who received a recent diagnosis of pancreatic cancer. This article is incredibly helpful. Thank you for it.
On the IMA telehealth providers of integrative oncology, there were only 4 doctors and 1 nurse. Anything you can do to encourage like-minded practitioners to list themselves would be much appreciated.
I have emphysema as well as lung cancer. How risky is propranolol for me? My emphysema has been fairly stable for the past 2 years, managed well with Trelegy Ellipta, and I do not suffer "exacerbations." It sounds like it could be a valuable repurposed drug to add to my protocol.
No, just use the lowest tolerable dose
No.. the benefit is seen with non-selective B blockers such as propranolol
So it's a beta-two function, then. Oh, well... But thanks for answering!
Might be worth asking your doctor if propanol would be effective for your heart condition instead of metoprolol. I took metoprolol for a while for blood pressure but discontinued on my own when my heart rate was routinely falling below 50 at night.
Thanks..
I think many integrative practitioners stay in the shadows to protect themsleves
I would start with a low dose 20mg once a day then twice a day and if you tolerate to increase to 40mg twice a day.
Thanks..
Thanks kindly..
One question: Would metoprolol provide the same protective effect? It's a selective beta-blocker (beta-one blocker) rather than a non-selective blocker like propranolol. I ask because I'm on high doses of metoprolol for a heart condition, so adding propranolol doesn't sound like a good idea for me. Oh, and my bp is usually in the high 80s/mid 40s range, so even less of a good idea to add propranolol...
Propranolol almost sounds like a miracle drug - but what do you do if it causes severe headaches and further drops in blood pressure for a person with already permanently low blood pressure... Is there any medication of similar profile and effect, perhaps?
Youu
Td
That's ridiculous; "Keep doing everything stressful, then take a pill to block signaling." That's like processing out nutrients from cereal, then adding them back to fortify the cereal.
And you did not define stress. People blame chronic stress for everything but skip over the definition; "the physiological or psychological response of the brain and body to any internal or external demand, challenge, or threat".
That's the definition of Life. Seems unlikely that we have a more stressful life than our ancestors. Did they have pills back then?
Oh if your solution were only as easy as it sounds…. Sometimes people…All people…get stuck in terrible circumstances beyond their power to change (think Covid insanity/lockdown) and the result is “Stress”… not usual stress but the kind created by demons and “enforced” by their useful idiots in media and politics! Then again Millions die from stress induced heart attacks, strokes, and cancer every year…. If a beta blocker can help someone through a stressful period then thats ok as long as its not addictive or toxic! The Chinese have a few very good herbal formulas which have been around for centuries which are specific for stress! Xiao Yao Wan is the classic and its over 1000 years old!!
What an in depth analysis! Thank you Dr. Marik! When do you rest? Happy 250 celebration!
Great work! Growing research suggests that stress-related pathways, including beta-adrenergic signaling, may influence processes such as inflammation, angiogenesis, immune function, and tumor progression, making this an important area of ongoing investigation. At the same time, it’s important to remind ourselves that promising biological mechanisms do not automatically translate into established clinical practice. While propranolol and other beta-blockers have shown intriguing findings in preclinical studies and some observational research, their role as adjunctive cancer therapies remains under active investigation. Larger, well-designed randomized clinical trials are needed before they can be routinely recommended for this purpose outside of established indications. Perhaps one of the most exciting developments in oncology is the growing recognition that cancer is influenced not only by the tumor itself but also by the broader physiological environment in which it exists. Understanding how the nervous system, immune system, and metabolism interact with cancer biology may ultimately lead to more comprehensive and personalized treatment strategies. Thanks for sharing this insightful overview.
This makes complete sense to me as a person taking metoprolol for one of the listed medical reasons and also as a registered nurse, this makes complete sense that this Rx would have a positive effect on lessening the risk of cancer. There definitely is an anti-anxiety component to this medication and of course that makes sense that that has a positive effect. Thank you you. I appreciate having this document!
I'm doing the research for my best friend, who received a recent diagnosis of pancreatic cancer. This article is incredibly helpful. Thank you for it.
On the IMA telehealth providers of integrative oncology, there were only 4 doctors and 1 nurse. Anything you can do to encourage like-minded practitioners to list themselves would be much appreciated.
I have emphysema as well as lung cancer. How risky is propranolol for me? My emphysema has been fairly stable for the past 2 years, managed well with Trelegy Ellipta, and I do not suffer "exacerbations." It sounds like it could be a valuable repurposed drug to add to my protocol.