Leading Edge is featured in this article and they are also recommending DMSO for their cancer patients (myself being one) yet you wrote "Dimethyl sulfoxide (DMSO) – not clinically useful and potentially harmful." Have you come up with new information? If so I'd love to know what it is as the Midwestern Doctor is also supportive.
I am confused too. I cant find any English language literature to support the use of DMSO in cancer… why dont you research this yourself . Furthermore, I do not know the background of TMD … he hides behind his pseudonym. I am not even sure he is even a doctor and if he is, what kind of doctor and his training. I have to be 100% scientifically honest. After having written over 500 peer revised scientific articles, and being an Editor for many journals, I do have some expertise in reviewing the literature. I know Dr Kory believes in TMD.. so I respect his opinion and we can have an honest disagreement. As I said I have to bee 100% sure of the recommendations I make and I am therefore more conservative than Dr Kory.
Thanks for the very quick reply! I believe that Dr. Kory knows TMD personally, certainly enough to say if he’s an MD. I’m NOT an MD so while I can pull out the DMSO studies that he mentions from that link, I can’t properly evaluate them.
Cancer differentiation / reversion (cell studies + reviews)
Perhaps start at the bottom then as those are the human clinical studies. Thanks for all that you do, btw. I keep trying to get my cancer docs to read your Cancer Care book asking them to find the flaws; they never have.
Human clinical studies / trials (directly supporting DMSO in cancer care)
I mean this respectfully, but do you all discuss these topics with practicing oncologists? This whole piece feels strangely dated. It talks about oncology as if we are still practicing in a mostly chemotherapy-centered era, when by now the field has already shifted substantially. In several major diseases, antibody-drug conjugates, targeted therapies, immunotherapy and cellular therapies have become central parts of standard care. That is especially true in breast, bladder, and lung cancer, lymphoma, myeloma, where newer agents have clearly changed treatment pathways. Immunotherapy is also now included into the management of more than 15+ cancer types, with FDA approvals continuing to expand across settings and biomarkers. So while repurposing is worth studying, any serious discussion of modern oncology should at least acknowledge how much the standard field has already evolved beyond conventional chemotherapy alone.
I think the context here is not that oncology/cancer related treatments are stuck back in formerly single treat.ent orthodoxy but that main stream cancer therapy is stuck in Big Pharma patented only solutions a d are the mainstays at pretty much all medical schools, especially those relying on massive funding to support University fat.
Hello Dr. Marik, and thank you for your work. I am not a physician. Nevertheless, I am surprised by your ranking of DMSO and CDS. The extensive work of Dr. AMD indicates the opposite for DMSO, and that of Drs. Kalcker and Xuewu Liu (and even Dr. Kory) also indicates the opposite for CDS. In short, you understand that if even independent physicians, free from medical dogma and conducting in-depth studies on the same subject, find themselves in complete disagreement, it raises many questions and generates doubt. Thank you for clarifying your position. Sincerely, P. Lasbats.
Labats. Thanks for your http://comments.My evaluation is based on an extensive review of the literature.. and I also err on the side of being safe and conservative. As far as DMSO it lacks scientific data for cancer; it may be effective for musculoskeletal disorders but not cancer. As far a chloride dioxide there are 5 case reports all very unconvincing. However, with some colleagues we have just written a very convincing case report on chloride dioxide; but the case is not in the public domain and not published so I cant rank it higher at this time. This is dynamic process and will change. One has to be scientifically honest.
Wow. Thanks for the cancer therapy update. Those charts are fantastic. Do you have any comment on ValAsta, which is astaxanthin with a glucose molecule attached? Mechanism is the cancer cell uptakes the glucose and once inside, the astaxanthin kills the cancer cell. I just saw a video on it yesterday.
Telomeres are repetitive DNA sequences and specialized proteins located at the ends of linear chromosomes that protect genetic material from degradation, fraying, or fusion with other chromosomes. Telomere length acts as a biological clock, shortening slightly with each cell division due to the "end replication problem," eventually triggering cellular senescence or death when they reach a critical limit.
Thank you for this thought-provoking piece. I love how you explored the potential of repurposed drugs and nutraceuticals as part of a broader therapeutic strategy. The idea of leveraging existing compounds with known safety profiles is both practical and appealing, particularly in areas where treatment options remain limited. What stood out to me most is the emphasis on mechanism-driven approaches: targeting inflammation, metabolic pathways, and cellular signaling rather than focusing solely on single-disease frameworks. That said, one aspect that might further strengthen the piece would perhaps be to more clearly differentiate between mechanistic rationale, early-stage or observational data, and robust clinical trial evidence. Given the complexity of polypharmacy and supplement use, especially in vulnerable populations, clarity around levels of evidence and potential interactions would help guide safer and more informed application. Such an engaging and forward-looking read!
yes i am aware of the https://zenodo.org/records/19455636 study. it has many limitations, i will be posting in a few hour followed by the most important post on a powerful strategy.
I think he has been influenced by the MWD. I have no idea who the MWD is and his clinical experience (if indeed he is a doctor). While DMSO has proven scientific benefit in musculoskeletal issues there in almost no scientific data to support its use to treat cancer. This is however a dynamic situation. Should data become available or new data emerge showing DMSO has a role in cancer I would be happy to review the data. However, I need to be scientifically honest and err on the side of safety first. .
Dear Dr Marik, i’m already subscribed to cancer and metabolic healing Substack, but some of the information I’m interested in that you’re publishing is on a different. Substack called the metabolic nutritionist, more specifically the two parts series called “cancer resistance and interventions to mitigate resistance parts, one and two. So do I need to subscribe to more than one Substack in order to get Dr. Paul Marrick‘s information in one place?
The Metabolic Nutritionist is not my substack… she cross post my substack.
I will be posting this two part series soon on my substack. However, If you e-mail me I will send you a copy. I did not realize this would happen. Sorry pmarik@protonmail.com
Thank you for all the information and presenting it in a way that is easy to understand. My approach is to be proactive following the DCIS and a year ago It was suggested that I take NAC I appreciate the confirmation to not take it, which I did not because it’s a precursor to glutathione and it didn’t seem logical. During Covid I did take NAC and glutathione. I now wonder if they caused a proliferation of calcifications/DCIS which was undiagnosed at that time.
Hello Dr. Marik,
Leading Edge is featured in this article and they are also recommending DMSO for their cancer patients (myself being one) yet you wrote "Dimethyl sulfoxide (DMSO) – not clinically useful and potentially harmful." Have you come up with new information? If so I'd love to know what it is as the Midwestern Doctor is also supportive.
https://www.midwesterndoctor.com/p/hundreds-of-studies-show-dmso-transforms
I'm confused.
I am confused too. I cant find any English language literature to support the use of DMSO in cancer… why dont you research this yourself . Furthermore, I do not know the background of TMD … he hides behind his pseudonym. I am not even sure he is even a doctor and if he is, what kind of doctor and his training. I have to be 100% scientifically honest. After having written over 500 peer revised scientific articles, and being an Editor for many journals, I do have some expertise in reviewing the literature. I know Dr Kory believes in TMD.. so I respect his opinion and we can have an honest disagreement. As I said I have to bee 100% sure of the recommendations I make and I am therefore more conservative than Dr Kory.
Thanks for the very quick reply! I believe that Dr. Kory knows TMD personally, certainly enough to say if he’s an MD. I’m NOT an MD so while I can pull out the DMSO studies that he mentions from that link, I can’t properly evaluate them.
Cancer differentiation / reversion (cell studies + reviews)
Friend erythroleukemia differentiation by DMSO (seminal early work, 1971) — linked on the page via PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC388942
Cancer differentiation review noting DMSO’s differentiation effects (2023 review PDF) — https://www.cancerdiagnosisprognosis.org/storage/cdp/3/1/cdp-3-1.pdf
DMSO induces differentiation (general / early cancer differentiation literature) — PubMed link in the page: https://pubmed.ncbi.nlm.nih.gov/5676741/
Dedifferentiation / cancer biology context (review article, PMC) — https://pmc.ncbi.nlm.nih.gov/articles/PMC8860064/
DMSO alters cytoskeleton in melanoma cells (FASEB abstract / report) — https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fasebj.2022.36.S1.R5690
Growth inhibition / anti-proliferation (animal + cell studies)
DMSO inhibits breast cancer growth in mice (tumor model; 2014) — https://synapse.koreamed.org/articles/1036489
DMSO reduces viability of breast and lung cancer cells (cell study; 2019) — https://link.springer.com/article/10.1007/s00418-019-01775-7
DMSO as anti-proliferative agent in multiple cancer cell lines (BMRAT paper) — https://bmrat.com/index.php/BMRAT/article/view/614
Very low concentrations of DMSO affect biochemical activity of cancer cells (2021, MDPI IJMS) — https://www.mdpi.com/1422-0067/22/6/2819
Oral DMSO slows aggressive prostate cancer in rats (1989, Wiley abstract page) — https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.2990150206
DMSO impacts tumor microvasculature / permeability (MRI tumor study; 2008, LWW abstract page) — https://journals.lww.com/investigativeradiology/abstract/2008/05000/magnetic_resonance_imaging_assays_for_dimethyl.4.aspx
Injected DMSO regresses Dalton’s lymphoma tumors in mice (2011, PubMed) — https://pubmed.ncbi.nlm.nih.gov/21269693/
Immune activation / making tumors more “visible” to immunity
DMSO-treated tumor cells induce anti-tumor immunity (2016, PMC full text) — https://pmc.ncbi.nlm.nih.gov/articles/PMC4891044/
DMSO induces expression of MHC/H-2 antigens (J Immunol paper page) — https://journals.aai.org/jimmunol/article/134/4/2790/19444/Dimethyl-sulfoxide-induces-expression-of-H-2
Enhanced immune recognition after DMSO-induced antigen changes (AACR Cancer Research page) — https://aacrjournals.org/cancerres/article/45/12_Part_1/6362/489339/Enhanced-Immune-Recognition-of-H-2-Antigen
DMSO increases H-2 antigens / immune sensitivity in lymphoma context (JNCI abstract page) — https://academic.oup.com/jnci/article-abstract/80/4/263/914468
DMSO increases spleen ability to eliminate cancer cells (PubMed) — https://pubmed.ncbi.nlm.nih.gov/7063517/
DMSO modulates melanoma antigen expression (AACR Cancer Research page) — https://aacrjournals.org/cancerres/article/46/10/4953/490233/Modulation-of-B16-Melanoma-Antigen-Expression-by
DMSO potentiates immune response / T-cell factors (PubMed) — https://pubmed.ncbi.nlm.nih.gov/1055568/
Human clinical studies / trials (directly supporting DMSO in cancer care)
Post-surgery oral DMSO and improved 5-year survival in colon cancer (trial; PubMed landing) — https://pubmed.ncbi.nlm.nih.gov/8493453/
Controlled trial after partial gastrectomy for stomach cancer, daily oral DMSO improved survival (PubMed landing) — https://pubmed.ncbi.nlm.nih.gov/1591948/
Intravesical DMSO for bladder cancer, recurrence association with biomarker (1999 trial; PubMed) — https://pubmed.ncbi.nlm.nih.gov/10101598/
Cancer pain: 2-patient report (1967; PubMed) — https://pubmed.ncbi.nlm.nih.gov/5342266/
Metastatic cancer pain series (1967; NY Academy of Sciences page) — https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1967.tb34919.x
Advanced cancer pain trial: DMSO + sodium bicarbonate, morphine discontinuation (2011; PubMed) — https://pubmed.ncbi.nlm.nih.gov/21426213/
Jack. Can you e-mail me so we can chat. pmarik@protonmail.com
Thanks… I will look at these studies. As I recall many are old and in test tubes. Certainly no human data.
Perhaps start at the bottom then as those are the human clinical studies. Thanks for all that you do, btw. I keep trying to get my cancer docs to read your Cancer Care book asking them to find the flaws; they never have.
Human clinical studies / trials (directly supporting DMSO in cancer care)
Post-surgery oral DMSO and improved 5-year survival in colon cancer (trial; PubMed landing) — https://pubmed.ncbi.nlm.nih.gov/8493453/
Controlled trial after partial gastrectomy for stomach cancer, daily oral DMSO improved survival (PubMed landing) — https://pubmed.ncbi.nlm.nih.gov/1591948/
Intravesical DMSO for bladder cancer, recurrence association with biomarker (1999 trial; PubMed) — https://pubmed.ncbi.nlm.nih.gov/10101598/
Cancer pain: 2-patient report (1967; PubMed) — https://pubmed.ncbi.nlm.nih.gov/5342266/
Metastatic cancer pain series (1967; NY Academy of Sciences page) — https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1967.tb34919.x
Advanced cancer pain trial: DMSO + sodium bicarbonate, morphine discontinuation (2011; PubMed) — https://pubmed.ncbi.nlm.nih.gov/21426213/
In an upcoming post I review DMSO as well as other therapies that are of UNPROVEN value. Paul
I mean this respectfully, but do you all discuss these topics with practicing oncologists? This whole piece feels strangely dated. It talks about oncology as if we are still practicing in a mostly chemotherapy-centered era, when by now the field has already shifted substantially. In several major diseases, antibody-drug conjugates, targeted therapies, immunotherapy and cellular therapies have become central parts of standard care. That is especially true in breast, bladder, and lung cancer, lymphoma, myeloma, where newer agents have clearly changed treatment pathways. Immunotherapy is also now included into the management of more than 15+ cancer types, with FDA approvals continuing to expand across settings and biomarkers. So while repurposing is worth studying, any serious discussion of modern oncology should at least acknowledge how much the standard field has already evolved beyond conventional chemotherapy alone.
I think the context here is not that oncology/cancer related treatments are stuck back in formerly single treat.ent orthodoxy but that main stream cancer therapy is stuck in Big Pharma patented only solutions a d are the mainstays at pretty much all medical schools, especially those relying on massive funding to support University fat.
Hello Dr. Marik, and thank you for your work. I am not a physician. Nevertheless, I am surprised by your ranking of DMSO and CDS. The extensive work of Dr. AMD indicates the opposite for DMSO, and that of Drs. Kalcker and Xuewu Liu (and even Dr. Kory) also indicates the opposite for CDS. In short, you understand that if even independent physicians, free from medical dogma and conducting in-depth studies on the same subject, find themselves in complete disagreement, it raises many questions and generates doubt. Thank you for clarifying your position. Sincerely, P. Lasbats.
Labats. Thanks for your http://comments.My evaluation is based on an extensive review of the literature.. and I also err on the side of being safe and conservative. As far as DMSO it lacks scientific data for cancer; it may be effective for musculoskeletal disorders but not cancer. As far a chloride dioxide there are 5 case reports all very unconvincing. However, with some colleagues we have just written a very convincing case report on chloride dioxide; but the case is not in the public domain and not published so I cant rank it higher at this time. This is dynamic process and will change. One has to be scientifically honest.
Wow. Thanks for the cancer therapy update. Those charts are fantastic. Do you have any comment on ValAsta, which is astaxanthin with a glucose molecule attached? Mechanism is the cancer cell uptakes the glucose and once inside, the astaxanthin kills the cancer cell. I just saw a video on it yesterday.
Thanks. I have not heard of this compound. I will do some research. Paul
name of researcher samuel shepherd. This is the video I saw.
https://www.youtube.com/results?search_query=unveiling+astaxanthin%27s+secrets+samuel+shepherd
Great video and info. Thanks, MR!
Thank you Dr. Marik and Dr. Kory!!
wow, that’s a lot of knowledge provided, I am so glad I did a max on Vitamin D when I was told not to. Thank You, Thank You, Thank You!!!!
There were studies going on at UVA years ago showing how Metformin can lengthen the life of telomeres. Interesting!
So do walnuts, so I’ve read/
Please explain - “Lengthen the life of telomeres”
Telomeres are repetitive DNA sequences and specialized proteins located at the ends of linear chromosomes that protect genetic material from degradation, fraying, or fusion with other chromosomes. Telomere length acts as a biological clock, shortening slightly with each cell division due to the "end replication problem," eventually triggering cellular senescence or death when they reach a critical limit.
Cool paste job. You had written, “ … lengthen the life of ….”
Yes no did look it up to be more concise
Thank you for this thought-provoking piece. I love how you explored the potential of repurposed drugs and nutraceuticals as part of a broader therapeutic strategy. The idea of leveraging existing compounds with known safety profiles is both practical and appealing, particularly in areas where treatment options remain limited. What stood out to me most is the emphasis on mechanism-driven approaches: targeting inflammation, metabolic pathways, and cellular signaling rather than focusing solely on single-disease frameworks. That said, one aspect that might further strengthen the piece would perhaps be to more clearly differentiate between mechanistic rationale, early-stage or observational data, and robust clinical trial evidence. Given the complexity of polypharmacy and supplement use, especially in vulnerable populations, clarity around levels of evidence and potential interactions would help guide safer and more informed application. Such an engaging and forward-looking read!
https://justusrhope.substack.com/p/1-in-3-cancer-free-ivermectin-trial?r=1idysb&utm_medium=ios
yes i am aware of the https://zenodo.org/records/19455636 study. it has many limitations, i will be posting in a few hour followed by the most important post on a powerful strategy.
Do you guys talk?
Interesting info - I am confused as this article says DMSO potentially harmfully - but article links to a telehealth physician using DMSO.
Yes, I understand. I dont think that DMSO is his main approach. We obviously dont agree on this issue.
I think he has been influenced by the MWD. I have no idea who the MWD is and his clinical experience (if indeed he is a doctor). While DMSO has proven scientific benefit in musculoskeletal issues there in almost no scientific data to support its use to treat cancer. This is however a dynamic situation. Should data become available or new data emerge showing DMSO has a role in cancer I would be happy to review the data. However, I need to be scientifically honest and err on the side of safety first. .
Very informative. Thank you.
Thoroughly enjoy your content paul. Wondered if you could do one on doses/forms typically used for nutraceuticals
Wait. That’s coming soon
Great. Also do you have any books paul?
Yes. The second edition of my book is available at amazon.com. It is a bit dated. My posts will eventually form the 3rd edition.
Where do I go to create a personalized protocol here in the states??
That’s coming in future posts, If you e-mail me I can send you the information: pmarik@protonmail.com
Dear Dr Marik, i’m already subscribed to cancer and metabolic healing Substack, but some of the information I’m interested in that you’re publishing is on a different. Substack called the metabolic nutritionist, more specifically the two parts series called “cancer resistance and interventions to mitigate resistance parts, one and two. So do I need to subscribe to more than one Substack in order to get Dr. Paul Marrick‘s information in one place?
The Metabolic Nutritionist is not my substack… she cross post my substack.
I will be posting this two part series soon on my substack. However, If you e-mail me I will send you a copy. I did not realize this would happen. Sorry pmarik@protonmail.com
If a writer has multiple sections inside a single Substack publication, one paid subscription can give you access to all of those sections (
As I understand one subscription should give you access to both sections. Please let me know. Paul
I’m being asked to subscribe to “the metabolic Nutritionist” to see p1 and p2 of your 2 part cancer resistance and interventions series.
Thank you for all the information and presenting it in a way that is easy to understand. My approach is to be proactive following the DCIS and a year ago It was suggested that I take NAC I appreciate the confirmation to not take it, which I did not because it’s a precursor to glutathione and it didn’t seem logical. During Covid I did take NAC and glutathione. I now wonder if they caused a proliferation of calcifications/DCIS which was undiagnosed at that time.
diagnosis
❤️