I came across this information and have utilized it for slight cognitive decline of hubs and absolutely can tell the difference when he uses it. Research on intranasal insulin demonstrates its ability to bypass the blood-brain barrier via the olfactory and trigeminal nerves, delivering the hormone directly to the brain to improve cognitive function, memory, and gait. Clinical trials have shown that this non-invasive delivery method can enhance verbal memory and decision-making in patients with Alzheimer’s disease, mild cognitive impairment, and type 2 diabetes, while also increasing cerebral blood flow without causing significant systemic hypoglycemia.
Key Research Findings
Cognitive and Functional Benefits: Studies, including a Phase 2 trial by Beth Israel Deaconess Medical Center, found that intranasal insulin improved walking speed and cognitive metrics in older adults, suggesting utility for age-related functional decline.
Alzheimer’s Treatment Potential: Pilot studies led by Wake Forest University and the VA confirmed that nasal insulin reaches key memory regions like the hippocampus and amygdala, improving memory in patients with early-stage dementia.
Also, I carry your sepsis protocol in my phone - so when I was told he had sepsis - what did I do - turned into jelly knees and held back my tears - however, quite sure had I had my wits no doc would listen to me, an old housefrau. BUT his D levels were 80 before the surgery that caused the sepsis and 50 when readmitted for said sepsis. Which he did really well at 74, next day back to normal. Interesting.
Love your work and have followed you since you testifying in front of a committee and the hospital squelching your life saving protocols. God bless you, your courage and the ability to continue to enlighten and fight!
Is this in reply to my question? For some reason, your responses only show up as independent comments and not as replies to individual comments/questions. I’m not sure if this is a glitch or if you need to make sure you hit reply under each comment you are replying to in order to make sure it’s clear which comments you are answering with what. 😊
Thanks for everything you do to share your wealth of knowledge!
That's the guideline consensus, but that's a lot of work.
Need a quantified benefit for all that work.
The "up to 40% of dementia cases may be preventable" figure is a population attributable fraction from the Lancet Commission - it assumes full causality across all nine factors and complete elimination of every one at the population level; that's not individual risk reduction.
No mention of APOE4? That's the dominant non-age risk factor for dementia.
"Clinical trials demonstrate that combined interventions outperform single strategies." Sounds great but is weakly supported: FINGER was modestly positive, but MAPT and PreDIVA were null, and US POINTER showed improvement in both arms.
My advice - absolutely try to avoid dementia in the first place. Prevention is far more effective than intervention. A no carb diet and resistance training and walking and selected nutriceuticals are the best you can do. Maybe higher dose melatonin at night (10 - 30 mg), also. Melatonin has no LD50 according to Dr. Reiter.
I disagree. A no carb diet is slowly but surely reducing the livers strength & resilience. It's accumulating fat which comes with protein. No carb protein/high fat diets reduce a systems toxin clearance abilities over time. Why prevention studies using this approach, only produce some cognitive improvements while bp, cholesterol, diabetes still get medicated. Why they only use those at risk of dementia & early MCI in protein/fat diet studies. No carb diets don't help when yr carb based system is already struggling.
The right diet will normalise all dementia precursor health conditions & improve cognitive function in this cohort & beyond.
Dementia is all about not clearing toxins from the brain.
Instead of supporting your system, a no or low carbon diet creates far more systemic stress, ot also affects the adrenals. If you're young, fine, do no carb, make yr system work much harder everyday than it needs to. just remember you're wearing down yr system quicker than normal.
Everyone who was chronically sick on a carb diet gets well within a few weeks on a meat diet. Should be all the proof anyone needs - why overthink it?
Consider also that a carb diet is a sugar diet. All carbs, broccoli too, turn into glucose sugar when eaten. Do you think a diet that rots teeth and balloons you up is a species-appropriate diet?
Of course a carb diet is a bonanza for the $4.9 Trillion (every single year) healthcare industry, as well as Big Agriculture. Could they be behind the everyday programming that carbs are good for you and meat is bad for you? Is that a possibility?
Note that we humans are essentially soft robots very easily programmed. The way to do it is consistent messaging, which is what the media does. The media programs, it does not inform. Science has found the ideal human programming technique is to slightly change the message every time. Before long people will believe anything; we live in a virtual reality of manufactured lies. Those lies are not for your benefit.
According to Ai:
"A low-carbohydrate or no-carb diet does not inherently reduce the liver's strength or resilience. In fact, clinical research demonstrates that limiting carbohydrates often improves liver health by rapidly reducing accumulated liver fat and fighting metabolic stress."
and
"Current scientific evidence does not show that low-carbohydrate, high-fat diets inherently reduce the body's long-term toxin clearance abilities in healthy people."
We'll see about that when I do my non-system aligned trials.
Whether it's refined sugar accompanied by fat or high fat /protein diets, they both destroy the human health system. So you're playing right into their arms. Let's talk in 5 or 10 years and see where your health biomarkers are at.
Some modern turmeric formulations offer greater bioavailability (such as CurQfen (reference video), Longvida, Meriva, or Theracurmin) and are typically standardized to total curcuminoids, not just pure curcumin.
Participants who received CurQfen (referenced in the report) showed significant improvements in memory, attention, and overall cognitive function compared to the placebo group. The authors attribute part of the effect to this formulation's ability to deliver more curcumin to the brain and cross the blood-brain barrier more effectively.
The situation in 2025-2026 is interesting: highly bioavailable formulations (CurQfen, Theracurmin, Longvida, and others) are showing more promising results than conventional curcumin, but there is still insufficient evidence to definitively claim that they prevent or treat Alzheimer's disease.
The three formulations with the greatest clinical interest for cognition remain:
---Theracurmin (nanodispersion).
---Longvida (solid lipid matrix).
--CurQfen (complex with fenugreek fiber).
Theracurmin is probably the formulation with the most clinical evidence for cognition. In long-term studies (up to 18 months), improvements or less decline in memory and attention were observed compared to placebo.
In 2026, the picture is roughly as follows:
---Theracurmin continues to have one of the best long-term clinical trials (18 months).
---CurQfen is gaining attention because it generates relatively high levels of free curcumin and has recent studies on mild cognitive impairment.
Longvida attracts interest due to its potential to reach the brain via its lipid system
My research suggests 95% of cases can be prevented. The other 5% is a generous allocation for genetic influences.
My Brain Regeneration Framework hypothesis paper, still adding citations, so not yet published, is system focused and seeks to address the systemic issues listed above using plant medicine & nutrients.
Initial case studies suggest it has great potential to not only stop neurodegeneration over time, but in some cases, ie brains not severely damaged & with capacity, to support some structural repair & neurogenesis.
The human system just needs the right support so it can repair metabolism & clearance mechanisms, etc.
For some of the research showing that low 25-hydroxyvitamin D (as measured in "vitamin D" blood tests) is a very strong risk factor for Parkinson's disease, dementia with Lewy bodies, multiple system atrophy etc. please see: https://vitamindstopscovid.info/00-evi/#3.3.
These three are actually the same disease, differing somewhat in their symptoms, but not the final outcome - motor disability, dementia and death. The difference is in the exact pattern of misfolding of the one α-synuclein protein.
At the start of this page you can find research which shows that the immune system needs at least 50 ng/mL circulating 25-hydroxyvitamin D to function properly.
Also, recommendations for how much vitamin D3 to supplement, on average, per day to attain this, without the need for blood tests or medical monitoring. These recommendations are from New Jersey based Professor of Medicine, Sunil Wimalawansa. The amount depends on body weight, with higher ratios for those suffering from obesity. For 70 kg (154 lb) body weight, without obesity, 125 micrograms (5000 IU) a day is a good amount.
Thanks, Dr. Marik! I’m doing some of what you wrote about already especially most nights getting lots of sleep for my age! I need to
go back to intermittent fasting as well. I remember in the past when someone said fasting was not good for us. Now we can. A new skill? Maybe I need to get back to what I was doing before I was caregiving my husband. Call it a new skill to remember how to do part of it again. I totally agree on exercise and fitness. And I have given much thought to the food we eat! This is a good article to incorporate more of it into my life. Closer to 80 than 70 retired RN!
Scientists working in various research groups worldwide have analyzed the biochemical content of beets in terms of their potential to inhibit the progression of neurodegenerative diseases. The presence of numerous chemical compounds, including betalain pigments, phenols, and saponins, was confirmed in the vegetable. Beets demonstrate a high antioxidant potential. This is due not only to the presence of betalain pigments but also to phenolic compounds such as ferulic, gallic, and vanillic acids. In addition to bioactive compounds, beets also contain inorganic compounds such as nitrates. Nitric oxide (II) is formed as a result of their transformation, which not only reduces blood pressure but can also improve blood circulation and brain oxygenation. In the elderly, blood supply to the brain is impaired. Tissue hypoxia impairs intellectual performance and can cause neurodegenerative diseases. As mentioned, nitric oxide (II) causes vasodilation and facilitates oxygen flow. This review analyzed these bioactive compounds (pigments, phenols, saponins) and summarized the results of relevant experimental studies using animal models. The overall results are promising, and further in-depth research on the potential uses of beetroot products in the prevention of diseases such as Alzheimer's disease should be pursued.
Areas with higher levels of PM2.5 (from traffic, industry, fires, and agriculture) have a higher concentration of dementia cases. The most affected states are typically in the West (due to fires) and parts of the Midwest (due to agriculture and industry). According to the NIH, the types of PM2.5 most associated with dementia come from agriculture and wildfires, which implies a greater risk in states such as: California, Oregon, and Washington (frequent fires); Idaho, Montana, and Nevada (seasonal smoke and regional pollution); and Iowa, Nebraska, Kansas, and Illinois (intensive agriculture).
A comprehensive review of how fine particulate matter, metals, and organic compounds affect the brain, including the risk of Alzheimer's and Parkinson's disease. The effects are stronger in people without the APOE ε4 gene, suggesting that pollution may act as an independent environmental factor. (Emory University)
APOE ε4 is the largest genetic risk factor for Alzheimer's disease. However, in this study, air pollution showed a stronger impact in non-carriers, suggesting that: Pollution may initiate or accelerate neurodegenerative processes even in people without a genetic predisposition. In APOE ε4 carriers, the genetic risk is so high that pollution adds relatively less additional risk.
I came across this information and have utilized it for slight cognitive decline of hubs and absolutely can tell the difference when he uses it. Research on intranasal insulin demonstrates its ability to bypass the blood-brain barrier via the olfactory and trigeminal nerves, delivering the hormone directly to the brain to improve cognitive function, memory, and gait. Clinical trials have shown that this non-invasive delivery method can enhance verbal memory and decision-making in patients with Alzheimer’s disease, mild cognitive impairment, and type 2 diabetes, while also increasing cerebral blood flow without causing significant systemic hypoglycemia.
Key Research Findings
Cognitive and Functional Benefits: Studies, including a Phase 2 trial by Beth Israel Deaconess Medical Center, found that intranasal insulin improved walking speed and cognitive metrics in older adults, suggesting utility for age-related functional decline.
Alzheimer’s Treatment Potential: Pilot studies led by Wake Forest University and the VA confirmed that nasal insulin reaches key memory regions like the hippocampus and amygdala, improving memory in patients with early-stage dementia.
Also, I carry your sepsis protocol in my phone - so when I was told he had sepsis - what did I do - turned into jelly knees and held back my tears - however, quite sure had I had my wits no doc would listen to me, an old housefrau. BUT his D levels were 80 before the surgery that caused the sepsis and 50 when readmitted for said sepsis. Which he did really well at 74, next day back to normal. Interesting.
Love your work and have followed you since you testifying in front of a committee and the hospital squelching your life saving protocols. God bless you, your courage and the ability to continue to enlighten and fight!
Thank you Dr Marik. Always great information
Sorry.. seems like I have a lot to say.. I have a large backup of post waiting in line.. I know I should slow down a bit. Thanks for reading. Paul
Thanks for this..
Agree...
Thanks..
Agree... thanks.
Sorry; I dont have any strong thoughts.
Is this in reply to my question? For some reason, your responses only show up as independent comments and not as replies to individual comments/questions. I’m not sure if this is a glitch or if you need to make sure you hit reply under each comment you are replying to in order to make sure it’s clear which comments you are answering with what. 😊
Thanks for everything you do to share your wealth of knowledge!
- 150–300 minutes/week aerobic activity
- Resistance training 2–3 times/week
That's the guideline consensus, but that's a lot of work.
Need a quantified benefit for all that work.
The "up to 40% of dementia cases may be preventable" figure is a population attributable fraction from the Lancet Commission - it assumes full causality across all nine factors and complete elimination of every one at the population level; that's not individual risk reduction.
No mention of APOE4? That's the dominant non-age risk factor for dementia.
"Clinical trials demonstrate that combined interventions outperform single strategies." Sounds great but is weakly supported: FINGER was modestly positive, but MAPT and PreDIVA were null, and US POINTER showed improvement in both arms.
My advice - absolutely try to avoid dementia in the first place. Prevention is far more effective than intervention. A no carb diet and resistance training and walking and selected nutriceuticals are the best you can do. Maybe higher dose melatonin at night (10 - 30 mg), also. Melatonin has no LD50 according to Dr. Reiter.
I disagree. A no carb diet is slowly but surely reducing the livers strength & resilience. It's accumulating fat which comes with protein. No carb protein/high fat diets reduce a systems toxin clearance abilities over time. Why prevention studies using this approach, only produce some cognitive improvements while bp, cholesterol, diabetes still get medicated. Why they only use those at risk of dementia & early MCI in protein/fat diet studies. No carb diets don't help when yr carb based system is already struggling.
The right diet will normalise all dementia precursor health conditions & improve cognitive function in this cohort & beyond.
Dementia is all about not clearing toxins from the brain.
Instead of supporting your system, a no or low carbon diet creates far more systemic stress, ot also affects the adrenals. If you're young, fine, do no carb, make yr system work much harder everyday than it needs to. just remember you're wearing down yr system quicker than normal.
Everyone who was chronically sick on a carb diet gets well within a few weeks on a meat diet. Should be all the proof anyone needs - why overthink it?
Consider also that a carb diet is a sugar diet. All carbs, broccoli too, turn into glucose sugar when eaten. Do you think a diet that rots teeth and balloons you up is a species-appropriate diet?
Of course a carb diet is a bonanza for the $4.9 Trillion (every single year) healthcare industry, as well as Big Agriculture. Could they be behind the everyday programming that carbs are good for you and meat is bad for you? Is that a possibility?
Note that we humans are essentially soft robots very easily programmed. The way to do it is consistent messaging, which is what the media does. The media programs, it does not inform. Science has found the ideal human programming technique is to slightly change the message every time. Before long people will believe anything; we live in a virtual reality of manufactured lies. Those lies are not for your benefit.
According to Ai:
"A low-carbohydrate or no-carb diet does not inherently reduce the liver's strength or resilience. In fact, clinical research demonstrates that limiting carbohydrates often improves liver health by rapidly reducing accumulated liver fat and fighting metabolic stress."
and
"Current scientific evidence does not show that low-carbohydrate, high-fat diets inherently reduce the body's long-term toxin clearance abilities in healthy people."
We'll see about that when I do my non-system aligned trials.
Whether it's refined sugar accompanied by fat or high fat /protein diets, they both destroy the human health system. So you're playing right into their arms. Let's talk in 5 or 10 years and see where your health biomarkers are at.
Some modern turmeric formulations offer greater bioavailability (such as CurQfen (reference video), Longvida, Meriva, or Theracurmin) and are typically standardized to total curcuminoids, not just pure curcumin.
Participants who received CurQfen (referenced in the report) showed significant improvements in memory, attention, and overall cognitive function compared to the placebo group. The authors attribute part of the effect to this formulation's ability to deliver more curcumin to the brain and cross the blood-brain barrier more effectively.
https://nutrition-evidence.com/article/5377/influence-of-curqfen-curcumin-on-cognitive-impairment-a-randomized-double-blinded-placebo-controlled-3-arm-3-sequence-comparative-study?utm_source=chatgpt.com (2023)
The situation in 2025-2026 is interesting: highly bioavailable formulations (CurQfen, Theracurmin, Longvida, and others) are showing more promising results than conventional curcumin, but there is still insufficient evidence to definitively claim that they prevent or treat Alzheimer's disease.
The three formulations with the greatest clinical interest for cognition remain:
---Theracurmin (nanodispersion).
---Longvida (solid lipid matrix).
--CurQfen (complex with fenugreek fiber).
Theracurmin is probably the formulation with the most clinical evidence for cognition. In long-term studies (up to 18 months), improvements or less decline in memory and attention were observed compared to placebo.
In 2026, the picture is roughly as follows:
---Theracurmin continues to have one of the best long-term clinical trials (18 months).
---CurQfen is gaining attention because it generates relatively high levels of free curcumin and has recent studies on mild cognitive impairment.
Longvida attracts interest due to its potential to reach the brain via its lipid system
https://www.mdpi.com/2076-3921/15/5/638?utm_source=chatgpt.com (2026)
https://pubmed.ncbi.nlm.nih.gov/29246725/ (2017)
https://pmc.ncbi.nlm.nih.gov/articles/PMC11421876/?utm_source=chatgpt.com (2024)
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1496661/full?utm_source=chatgpt.com (2024)
https://pmc.ncbi.nlm.nih.gov/articles/PMC12040662/?utm_source=chatgpt.com (2025)
My research suggests 95% of cases can be prevented. The other 5% is a generous allocation for genetic influences.
My Brain Regeneration Framework hypothesis paper, still adding citations, so not yet published, is system focused and seeks to address the systemic issues listed above using plant medicine & nutrients.
Initial case studies suggest it has great potential to not only stop neurodegeneration over time, but in some cases, ie brains not severely damaged & with capacity, to support some structural repair & neurogenesis.
The human system just needs the right support so it can repair metabolism & clearance mechanisms, etc.
Thank you, Dr. Marik.
For some of the research showing that low 25-hydroxyvitamin D (as measured in "vitamin D" blood tests) is a very strong risk factor for Parkinson's disease, dementia with Lewy bodies, multiple system atrophy etc. please see: https://vitamindstopscovid.info/00-evi/#3.3.
These three are actually the same disease, differing somewhat in their symptoms, but not the final outcome - motor disability, dementia and death. The difference is in the exact pattern of misfolding of the one α-synuclein protein.
At the start of this page you can find research which shows that the immune system needs at least 50 ng/mL circulating 25-hydroxyvitamin D to function properly.
Also, recommendations for how much vitamin D3 to supplement, on average, per day to attain this, without the need for blood tests or medical monitoring. These recommendations are from New Jersey based Professor of Medicine, Sunil Wimalawansa. The amount depends on body weight, with higher ratios for those suffering from obesity. For 70 kg (154 lb) body weight, without obesity, 125 micrograms (5000 IU) a day is a good amount.
Thanks, Dr. Marik! I’m doing some of what you wrote about already especially most nights getting lots of sleep for my age! I need to
go back to intermittent fasting as well. I remember in the past when someone said fasting was not good for us. Now we can. A new skill? Maybe I need to get back to what I was doing before I was caregiving my husband. Call it a new skill to remember how to do part of it again. I totally agree on exercise and fitness. And I have given much thought to the food we eat! This is a good article to incorporate more of it into my life. Closer to 80 than 70 retired RN!
Scientists working in various research groups worldwide have analyzed the biochemical content of beets in terms of their potential to inhibit the progression of neurodegenerative diseases. The presence of numerous chemical compounds, including betalain pigments, phenols, and saponins, was confirmed in the vegetable. Beets demonstrate a high antioxidant potential. This is due not only to the presence of betalain pigments but also to phenolic compounds such as ferulic, gallic, and vanillic acids. In addition to bioactive compounds, beets also contain inorganic compounds such as nitrates. Nitric oxide (II) is formed as a result of their transformation, which not only reduces blood pressure but can also improve blood circulation and brain oxygenation. In the elderly, blood supply to the brain is impaired. Tissue hypoxia impairs intellectual performance and can cause neurodegenerative diseases. As mentioned, nitric oxide (II) causes vasodilation and facilitates oxygen flow. This review analyzed these bioactive compounds (pigments, phenols, saponins) and summarized the results of relevant experimental studies using animal models. The overall results are promising, and further in-depth research on the potential uses of beetroot products in the prevention of diseases such as Alzheimer's disease should be pursued.
https://www.mdpi.com/2076-3417/13/2/1044 (2023).
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Areas with higher levels of PM2.5 (from traffic, industry, fires, and agriculture) have a higher concentration of dementia cases. The most affected states are typically in the West (due to fires) and parts of the Midwest (due to agriculture and industry). According to the NIH, the types of PM2.5 most associated with dementia come from agriculture and wildfires, which implies a greater risk in states such as: California, Oregon, and Washington (frequent fires); Idaho, Montana, and Nevada (seasonal smoke and regional pollution); and Iowa, Nebraska, Kansas, and Illinois (intensive agriculture).
https://www.nih.gov/news-events/nih-research-matters/air-pollution-linked-dementia-cases?utm_source=copilot.com
Chronic exposure to air pollutants increases the risk of cognitive decline and Alzheimer's disease, according to US data.
https://www.health.harvard.edu/blog/does-air-pollution-cause-alzheimers-disease-2020072320627?utm_source=copilot.com (2025)
A 2024 study analyzing donated brains in the US shows that PM2.5 exposure increases the accumulation of amyloid-beta plaques.
https://sph.emory.edu/news/traffic-pollution-alzheimers?utm_source=copilot.com (2024)
A comprehensive review of how fine particulate matter, metals, and organic compounds affect the brain, including the risk of Alzheimer's and Parkinson's disease. The effects are stronger in people without the APOE ε4 gene, suggesting that pollution may act as an independent environmental factor. (Emory University)
APOE ε4 is the largest genetic risk factor for Alzheimer's disease. However, in this study, air pollution showed a stronger impact in non-carriers, suggesting that: Pollution may initiate or accelerate neurodegenerative processes even in people without a genetic predisposition. In APOE ε4 carriers, the genetic risk is so high that pollution adds relatively less additional risk.
https://www.environmentalhealth.ucdavis.edu/air-pollution/brain-health?utm_source=copilot.com (2025)
https://news.emory.edu/stories/2024/04/hs_air_pollution_and_alzheimers_10-04-2024/story.html?utm_source=copilot.com (2025)