THE CANCER & METABOLIC LIBRARY

Table of Contents

Welcome to the Cancer Library

This Cancer Library is designed to become a comprehensive, evidence-informed repository covering every major aspect of cancer—from the biology of cancer and metabolic theory to repurposed drugs, nutraceuticals, diet, conventional oncology, cancer-specific treatment strategies, prevention, survivorship, and the future of cancer care. The goal is not simply to collect articles, but to build a practical, continuously evolving educational resource for patients, caregivers, and healthcare professionals seeking a broader understanding of cancer and its treatment. This is a not just s list of Substack posts but rather a DIGITAL TEXTBOOK.

This is a living document. Many of the titles listed below have already been published and are linked to their corresponding articles (hyperlinks). Others represent posts that are still in development and therefore do not yet have hyperlinks. As new articles are written, the library will continue to expand, sections will be reorganized, and additional topics will be added. Over time, I hope this dynamic Table of Contents will evolve into one of the most comprehensive collections of information available on metabolic and integrative approaches to cancer care, providing readers with a single resource that grows alongside our understanding of this rapidly evolving field.

Topics marked with a double asterisk (**) represent foundational or particularly important posts and are recommended as essential reading for anyone new to the library.

The CANCER Library

A Different Way of Thinking About Cancer

• Marik’s Cancer & Metabolic Healing Playbook

• Cancer Is a Metabolic Disease**

• Oncologists: Cancer is a Metabolic Disease

• The Metabolic approach to treating cancer

• What is integrative oncology

• The Metabolic Trap: The five-axis metabolic pressure model **

• Ivermectin: a network amplifier in the metabolic cancer trap **

• Not All Cancers Are the Same: Which Tumors May Be Most Vulnerable to a Five-Axis Strategy? **

• Targeting glycolytic enzymes in cancer cells

• Repurposed Drugs and Nutraceuticals: A New Frontier in Cancer Therapy **

• Approach to repurposed drugs in cancer (updated) **

The Biology of Cancer

The Warburg Effect and Metabolic Reprogramming

• The Warburg Revolution: Rewriting Cancer Through the Lens of Metabolism. A six part series

• The Deadliest Cancers Have the Strongest Warburg Effect

• Lactate—The Fuel That Builds Tumors

• c-Myc, GLUT1, and Hexokinase-2—Cancer’s Sugar Addiction Machinery

• PI3K-AKT-mTOR—The Master Switch of Cancer Metabolism

• Nutraceuticals That Target the Warburg Network

• Repurposed Drugs That Target Cancer Metabolism

Fatty Acid Oxidation

• Cancers With Strong Fatty Acid Oxidation (FAO) and OXPHOS Dependence

• Does the fact that cancers may depend on fatty acid oxidation negate the metabolic theory of cancer (Warburg Effect)

• Cancer, Warburg and Fatty Acid Oxidation: A Clearer Understanding

Cancer Stem Cells and Tumor Ecology

• Cancer Stem Cells

• Cancer Immunity

• Reprograming the immune system and tumor microenvironment

• Repurposed Drugs and Nutraceuticals That Improve Systemic Immunity and the Tumor Microenvironment **

Genes, Mutations and Limits of Precision Oncology

• The mutation trap: The Billion dollar illusion of precision oncology

• Which Comes First: Driver Mutations or the Warburg Effect?

• TP53: The Guardian of the Genome

• MYC: The Master Driver of Cancer Growth

• What Is a KRAS Mutation—and Why Does It Matter?

• Understanding the BRAF Mutation: One of Oncology’s Biggest Success Stories

• EGFR: The First Great Targeted Therapy

• BRCA1 and BRCA2: Beyond Breast Cancer

• APC and the Origins of Colorectal Cancer

• Cancer Is Not Defeated by a Single Target: Why Metabolic Flexibility Demands Multi-Target Therapy**

Diet, Metabolism and the Host

• Why diet is the foundation of the Metabolic Approach to Cancer **

• Insulin resistance

• Dietary interventions in cancer (part 1)

• Dietary interventions in cancer (part2)

• Role of fasting and fasting-mimicking diets (FMDs) during chemotherapy

• The Gut Microbiome and Cancer: What This New Study Tells Us—and Why It Matters

• B complex vitamins and anti-oxidants

• Omega 3 fatty acids

• Vitamin D

• Coffee in Patients With Metastatic Cancer: Potential Benefits, Limitations, and Practical Considerations

• Cancer Cachexia

Repurposed Drugs

Core Repurposed Agents

• Ivermectin

• Mebendazole

• Doxycycline

• Metformin

• Propranolol

• Statins

• Aspirin/Diclofenac (COX inhibitors)Aspirin

• Melatonin

Additional and Emerging Agents

• Artemisin

• Cimetidine

• Intravenous Vitamin C

• Itraconazole

• Low dose naltrexone (LDN)

• Mistletoe

• Niclosamide

• Thymosin alpha-1

Optimal Dosing

• The Ivermectin and Mebendazole Dosing Question: What Is the Optimal Dose for Cancer? **

• The Ivermectin and Mebendazole Dosing Question: Patient and Provider Responses

Nutraceuticals and Natural Compounds

• Curcumin

• EGCG and Green Tea

• Berberine

• Sulforaphane

• Resveratrol

• Luteolin/Genistein

• Quercetin

• Aged garlic extract

• Modified Citrus Pectin

• IP6 (Inositol Hexaphosphate)

• Honokoil

• Ashwagandha

Integrating Conventional and Metabolic Cancer Therapy

• The therapeutic paradox

• Overview of chemotherapy and metronomic dosing

• Integration with Metronomic Chemotherapy and repurposed drugs **

• Integrating Metronomic Chemotherapy with the Five-Axis Metabolic Approach to Cancer Treatment

• What is immunotherapy and why does it usually fail?

• Repurposed Drugs and Natural PD-L1/Multi-Target Compounds

• Layering Metabolic Therapy with Oncology

• Bridging the Gap: Can Repurposed Drugs and Nutraceuticals Bridge Periods of Conventional Therapy Interruption?

• Protecting Normal Tissue During and After Radiation: An Integrative Support Strategy

• Perioperative drugs to reduce metastases **

• PSK: The Forgotten Cancer Therapy That Improved Survival After Surgery

Resistance, Dormancy, Recurrence and survivorship

• Why cancers recur after “complete response”

• Cancer resistance and interventions to mitigate resistance- Part 1

• Cancer resistance and interventions to mitigate resistance- Part 2

• To Cycle or Not to Cycle: Rethinking Doxycycline and Mebendazole **

• Can Cancer Become Resistant to Treatment- and What Might Prevent it.

• Can Cancer Become Resistant to Repurposed Drugs and Nutraceuticals?

• Monitoring the progression of cancer

• When treatment fails: What next?

• What RGCC Cancer Testing Can — and Can’t — Tell You

• Maintenance Therapy After Achieving NED

• Personalized High Risk Maintenance Protocols

Preventing Cancer: The ROOTS Protocols

• What the Public Is Not Told About Cancer Prevention

• The ROOTS protocols **

• Preventing Breast Cancer

• Hormone Replacement Therapy: A Reevaluation and the Role of Bioidentical Hormones

• Preventing Colorectal Cancer

• Colonoscopy Versus Flexible Sigmoidoscopy for Colorectal Cancer Screening: An Evidence-Based Review

• Preventing Melanoma (Part 1)

• Preventing Melanoma (Part 2)

• Preventing Prostate Cancer

• PSA Screening

• Sunlight; medicine or carcinogen

Cancer-Specific Guides

Common Solid Tumors

• Breast Cancer

• Colorectal Cancer

• Lung Cancer (Part 1).

• Lung Cancer (Part 2)

• Pancreatic cancer

• Prostate cancer: (Part 1)

• Prostate Cancer (Part 2)

• Biochemical recurrence of Prostate Cancer (BCR)

• Uterine Cancer

• Thyroid Cancer

• Glioblasoma Multiforme (GBM)

Hematologic Cancers

• Follicular Lymphoma

• Hodgkin Lymphoma

• Diffuse Large B-Cell Lymphoma

• T-cell Lymphoma

Specialized Cancers

• Neuroendocrine Tumors (Part 1)

• Neuroendocrine Tumors (Part 2)

• HPV-Associated Oral Cancer

• Childhood cancers

• Turbo cancers

Experimental and Emerging Therapies

• Deuterium Depletion

• Red light therapy and methylene blue

• Potential adjunctive therapies **

• A Frog Derived Bacterium that Fights Cancer on Two Fronts

Myths, Misconceptions and Controversies

• Cancers are not caused by parasites

• Do Fungi Cause Cancer? The Short Answer Is No... But That’s Not the Whole Story

• Interventions with little or no scientific support (Part 1) **

• Interventions with little or no scientific support (Part 2) **

• Trusting The Science

The Patients Guide

• Questions every patient should ask their oncologist

• Choosing the right guide

• Getting a second opinion

• Understanding evidence

• Decoding Cancer Care: A Patient’s Guide to Medical Abbreviations

• Why Randomized Controlled Trials Are Poorly Suited to Testing Repurposed Drugs and Nutraceuticals in Cancer **

Patient Stories

• A Patients Story: Stage IV Urothelial Cancer to Remission

• From confusion to Clarity: A Result Worth Fighting For

Medicine, Oncology and the Bigger Picture

• What COVID Taught Me About Medicine **

• What Went Wrong: Doctors vs. Automatons **

• Societal impact of cancer

• The future of cancer treatment

• The Business Model of Modern Oncology

Metabolic Healing Library

• Insulin Resistance and the Metabolic Syndrome **

• Insulin resistance

• NASH

• Coronary artery disease and the Cholesterol Myth

• Hypertension: The Silent killer

• Good Fat, Bad Fat

• The Great Iodine Debate: From 150 Micrograms to 50 Milligrams

• Treatment of Influenza

• Intermittent Fasting, Metabolic Health, and Modern Disease

• Classical Ketogenic Diet, Paleo Diet, Carnivore Diet, Paleolithic Ketogenic Diet (PKD, and Mediterranean Diet: Differences, Mechanisms, and Potential Benefits

• The Serotonin Myth: Why SSRI’s So Often Fail” (Part 1)

• Depression Is Not What We Think It Is (Part 2)

• Treating Depression as a Whole-Body Disease (Part3)

• Preventing Cognitive Decline: A Multi-Axis, Systems-Based Approach

• Brain-Derived Neurotrophic Factor (BDNF): The Brain’s Master Growth Factor **

• Gut dysbiosis

• Beyond Anti-Seizure Drugs: A Metabolic Approach to Epilepsy

• Repurposed Drugs and Nutraceuticals for the Treatment of SLE and other autoimmune disorders.