THE CANCER & METABOLIC LIBRARY

Provisional Table of Contents

Welcome to the Cancer Library

This Cancer Library is designed to become a comprehensive, evidence-informed repository covering every major aspect of cancer—from the biology of cancer and metabolic theory to repurposed drugs, nutraceuticals, diet, conventional oncology, cancer-specific treatment strategies, prevention, survivorship, and the future of cancer care. The goal is not simply to collect articles, but to build a practical, continuously evolving educational resource for patients, caregivers, and healthcare professionals seeking a broader understanding of cancer and its treatment.

This is a living document. Many of the titles listed below have already been published and are linked to their corresponding articles (hyperlinks). Others represent posts that are still in development and therefore do not yet have hyperlinks. As new articles are written, the library will continue to expand, sections will be reorganized, and additional topics will be added. Over time, I hope this dynamic Table of Contents will evolve into one of the most comprehensive collections of information available on metabolic and integrative approaches to cancer care, providing readers with a single resource that grows alongside our understanding of this rapidly evolving field.

Topics marked with a double asterisk (**) represent foundational or particularly important posts and are recommended as essential reading for anyone new to the library.

The CANCER Library

Understanding Cancer Through A Different Lens

• Marik’s Cancer & Metabolic Healing Playbook

• What COVID Taught Me About Medicine

• What is integrative oncology

• Societal impact of cancer

• Cancer Is a Metabolic Disease**

• Oncologists: Cancer is a Metabolic Disease

• Why Randomized Controlled Trials Are Poorly Suited to Testing Repurposed Drugs and Nutraceuticals in Cancer **

The Metabolic Foundations of Cancer

• Cancer Stem Cells

• Cancer Immunity

• Repurposed Drugs and Nutraceuticals: A New Frontier in Cancer Therapy **

• Approach to repurposed drugs in cancer (updated) **

• Targeting glycolytic enzymes in cancer cells

• Reprograming the immune system and tumor microenvironment

• Repurposed Drugs and Nutraceuticals That Improve Systemic Immunity and the Tumor Microenvironment **

• Cancers With Strong Fatty Acid Oxidation (FAO) and OXPHOS Dependence

• Does the fact that cancers may depend on fatty acid oxidation negate the metabolic theory of cancer (Warburg Effect)

• Cancer, Warburg and Fatty Acid Oxidation: A Clearer Understanding

Metabolic Approaches to Cancer Control

• The Metabolic Trap: The five-axis metabolic pressure model **

• Ivermectin: a network amplifier in the metabolic cancer trap **

• Cancer resistance and interventions to mitigate resistance- Part 1

• Cancer resistance and interventions to mitigate resistance- Part 2

• To Cycle or Not to Cycle: Rethinking Doxycycline and Mebendazole **

• Perioperative drugs to reduce metastases **

• PSK: The Forgotten Cancer Therapy That Improved Survival After Surgery

The Warburg Revolution: A Series

• The Deadliest Cancers Have the Strongest Warburg Effect

• Lactate—The Fuel That Builds Tumors

• c-Myc, GLUT1, and Hexokinase-2—Cancer’s Sugar Addiction Machinery

• PI3K-AKT-mTOR—The Master Switch of Cancer Metabolism

• Nutraceuticals That Target the Warburg Network

• Repurposed Drugs That Target Cancer Metabolism

Diet & Metabolism

• Why diet is the foundation of the Metabolic Approach to Cancer **

• Insulin resistance

• Dietary interventions in cancer (part 1)

• Dietary interventions in cancer (part2)

• Role of fasting and fasting-mimicking diets (FMDs) during chemotherapy

• B complex vitamins and anti-oxidants

• Cancer Cachexia: Causes, Mechanisms, and Management

• Coffee in Patients With Metastatic Cancer: Potential Benefits, Limitations, and Practical Considerations

Understanding Cancer Mutations

• The mutation trap: The Billion dollar illusion of precision oncology

• What Is a KRAS Mutation—and Why Does It Matter?

• Understanding the BRAF Mutation: One of Oncology’s Biggest Success Stories

• TP53: The Guardian of the Genome

• PIK3CA and the PI3K–AKT–mTOR Pathway

• BRCA1 and BRCA2: Beyond Breast Cancer

• EGFR: The First Great Targeted Therapy

• MYC: The Master Driver of Cancer Growth

• APC and the Origins of Colorectal Cancer

Repurposed Drugs

• Aspirin/Diclofenac (COX inhibitors)Aspirin

• Artemisin

• Cimetidine

• Doxycycline

• Intravenous Vitamin C

• Itraconazole

• Ivermectin

• The Ivermectin and Mebendazole Dosing Question: What Is the Optimal Dose for Cancer? **

• The Ivermectin and Mebendazole Dosing Question: Patient and Provider Responses

• Low dose naltrexone (LDN)

• Mebendazole

• Metformin

• Melatonin

• Mistletoe

• Niclosamide

• Propranolol

• Statins

• Thymosin alpha-1

Nutraceuticals

• Aged garlic extract

• Berberine

• Curcumin

• EGCG and Green Tea

• Honokoil

• Modified Citrus Pectin

• Luteolin: A versatile anticancer agent (and Genistein).

• Resveratrol

• Sulforaphane

• Omega 3 fatty acids

• Vitamin D

Specific Cancers

• Breast Cancer

• Childhood cancers

• Colorectal Cancer

• Follicular Lymphoma

• Hodgkin Lymphoma Beyond Chemotherapy: Integrating a Five-Axis Metabolic Trap with Modern Immuno-Oncology

• HPV-Associated Oral Cancer

• Lung Cancer in the Era of Precision Oncology: Epidemiology, Molecular Biology, and Therapeutic Challenges (Part 1).

• Lung Cancer Beyond Precision Oncology: The Five-Axis Metabolic Trap as a Systems Biology Framework (Part 2)

• Neuroendocrine Tumors (Part 1)

• Neuroendocrine Tumors (Part 2)

• Pancreatic cancer

• Prostate cancer: (Part 1)

• Prostate Cancer (Part 2)

• Thyroid Cancer

• Turbo cancers

• Uterine Cancer

Patient Success Stories

• A Patients Story: Stage IV Urothelial Cancer to Remission

• From confusion to Clarity: A Result Worth Fighting For

Preventing Cancer: The ROOTS Protocols

• What the Public Is Not Told About Cancer Prevention

• The ROOTS protocols **

• Preventing Breast Cancer

• Hormone Replacement Therapy: A Reevaluation and the Role of Bioidentical Hormones

• Preventing Colorectal Cancer

• Colonoscopy Versus Flexible Sigmoidoscopy for Colorectal Cancer Screening: An Evidence-Based Review

• Preventing Melanoma (Part 1)

• Preventing Melanoma (Part 2)

• Preventing Prostate Cancer

• PSA Screening

Conventional Oncology Through a Metabolic Lens

• The therapeutic paradox

• What is immunotherapy and why does it usually fail?

• Layering Metabolic Therapy with Oncology

• Bridging the Gap: Can Repurposed Drugs and Nutraceuticals Bridge Periods of Conventional Therapy Interruption?

• Overview of chemotherapy and metronomic dosing

• Integration with Metronomic Chemotherapy and repurposed drugs **

• Integrating Metronomic Chemotherapy with the Five-Axis Metabolic Approach to Cancer Treatment

Monitoring and Survivorship

• Monitoring the progression of cancer

• Why cancers recur after “complete response”

• Maintenance Therapy After Achieving NED

• Personalized High Risk Maintenance Protocols

• When treatment fails: What next?

Specific therapeutic issues

• Red light therapy and methylene blue

• Sunlight; medicine or carcinogen

• Potential adjunctive therapies **

• Protecting Normal Tissue During and After Radiation: An Integrative Support Strategy

Patient Advocacy

• Questions Every Patient Should Ask Their Oncologist **

• Choosing the right guide

Myths, Misconceptions and Controversies

• Cancers are not caused by parasites

• Do Fungi Cause Cancer? The Short Answer Is No... But That’s Not the Whole Story

• Interventions with little or no scientific support (Part 1) **

• Interventions with little or no scientific support (Part 2) **

The Future of Cancer Care

• The Business Model of Modern Oncology

• The Future of Cancer Treatment: From Tumor Destruction to Systems Biology

• A Frog Derived Bacterium that Fights Cancer on Two Fronts

Metabolic Healing Library

• Insulin Resistance and the Metabolic Syndrome

• Insulin resistance

• NASH

• Coronary artery disease and the Cholesterol Myth

• Hypertension: The Silent killer

• Good Fat, Bad Fat

• Intermittent Fasting, Metabolic Health, and Modern Disease

• Classical Ketogenic Diet, Paleo Diet, Carnivore Diet, Paleolithic Ketogenic Diet (PKD, and Mediterranean Diet: Differences, Mechanisms, and Potential Benefits

• The Serotonin Myth: Why SSRI’s So Often Fail” (Part 1)

• Depression Is Not What We Think It Is (Part 2)

• Treating Depression as a Whole-Body Disease (Part3)

• Preventing Cognitive Decline: A Multi-Axis, Systems-Based Approach

• Gut dysbiosis

• Beyond Anti-Seizure Drugs: A Metabolic Approach to Epilepsy

• Repurposed Drugs and Nutraceuticals for the Treatment of SLE and other autoimmune disorders.

• Treatment of Influenza