I have used most of what you document in your article (my oncologist refused to prescribe metformin for me even though I showed him academic articles showing its synergy with chemo). If cancer is a metabolic disease and terrain is critical, then isn't the right nutrition at least half the story?
As a recovered cancer patient, I've done extensive research on which foods to eat and I've designed a system of nutrition to make it very easy for cancer patients or their carers to get the right nutrition, based on academic research. For example all of the foods in my system have anti cancer properties, or are at the very least neutral. It's vegan - meat and dairy free, which has been documented over and over as being the best for most cancer patients. Many believe that the keto diet is the best, but having been on that for over a year (while on chemo) I eventually discovered it's not - I read Dr Siegfried's book and everything else I could find on keto. Ultimately I came to the conclusion that while it may help glioblastomas (Dr Siegfried's specialist area), it is not right for most (it's also a very unnatural diet). Additionally, restricting or eliminating glucose is a stress on cancer for about 30 days but after that it emits signals to cause apoptosis in normal cells and picks up its new nutrition from the bloodstream.
I've also done research on which probiotic strains exert powerful effects (anti inflammation, immune modulation etc) and discovered synergistic pairings with plant exosomes (and their communication with specific probiotic strains) and turned these into 3 simple smoothie blends (I'm not yet sure if this should go into a separate book as there is a lot of research on which its based and a chapter on helping with dysbiosis). The nutrition book is almost complete. If you have any interest in reading it, pls let me know - it would take me about a week to bring it up to draft standard. it can be used with any treatment protocol. I would love to align what Ive found out with your research to make safe eating and nutrition as easy as possible for people facing this overwhelming challenge.
Thanks for your comments. I agree that nutrition is the foundation of any treatment approach.. and as you recognize one key does not fit all people. You can send me your synopsis at pmarik@protonmail.com.
Hello, I’m really interested in your book and research and would love to learn more about what you’ve found most helpful, particularly what has worked for you in helping you feel alive, in terms of energy, vitality, and overall wellbeing.
I’m also widely read in this area and familiar with approaches such as the ketogenic diet, as well as the work of Thomas Seyfried and Jane McLelland. I’m a cancer survivor myself, my diagnosis was a rare, slow-growing liposarcoma, which was surgically removed.
I’d be very interested to hear what has worked best for you in practice. If you’re open to sharing more, I’d be grateful if you could reach me at claudia.gasparini@alumni.griffithuni.edu.au. I’d love to hear from you. Many thanks, Claudia
I also read Jane McClellands book. Unfortunately by the time I got to the big reveal in chapter 11, I was suffering badly from chemo brain at the time and couldn’t understand any of it!
I’m happy to share what I know with anyone who’s interested. I’m not going to share here as this is Dr Marik’s platform, but while energy and vitality are difficult there are ways to improve that. Contact me directly if you want.
Thank you for sharing with Dr. Marik Your additional information on nutrition I believe it is largely my combined Dr Marik’s protocol and Supplements and Dr Makis Protocol. Dr. Marik responded to an earlier inquiry I had because my cancer is recurrent ovarian cancer which is contraindicated in some clinical papers for the ketogenic approach which he is acknowledging again here. Would be very interested if both you and Dr Marik Commented once he has reviewed your book and all of us will be very excited to hear of its completion and when it will be available. The only other Q I see that differs between the repurpose drug protocols in the Cancer care 2.0 book of Dr. Marik And the journal of ortho molecular medicine cellular cancer protocol Is seemingly great differences in the volume of mebenz/febenz. If anyone knows the answer to that it would be helpful as well. My cancer is very tricky right now and I want to make sure I am maximizing every aspect so I can get more response going since the chemo keeps failing but I am currently on one and I believe that if I could get an additional optimized confidence in Every aspect I don't know if Dr Marik Does telehealth or reviews medical treatment and repurposed and nutritional efforts on the part of the patient. God bless Dr. Marik, There is no way to overstate the sacrifices he has made to first bring the truth during the pandemic and suffer and then have his incredible illustrious career achievements in human medicine ripped away by corrupt institutions! Thank you all for this helpful conversation as we tried to stay alive with confidence and faith in God for making people like Paul!
Totally agree, diet is essential in dealing with cancer. Was just diagnosed with cancer and trying to put a daily protocol together to transition to another form of eating. Would love to learn what has worked for you! Email: wisandmo@aol.com
Hello all. I am on Paul Marik's protocol and have been since January 23. I am stage four recurrent ovarian. I was miraculously healed the first time around when I went in for a nine hour surgery of colon resections removals and debulking and there was no cancer. Diagnosed recurrent six months later and learned of the protocol in addition to going back to chemotherapy. This chemo is a bit different although still a platinum based and I am now running into iron deficiency does anyone have familiarity with success in increasing blood iron levels without getting into more pills etc, (especially since constipation is already a problem). I had two rounds of heme iron infusions but they obviously did not last very long since it has been less than two months my recent blood work showed hemochromia. Any input welcome I have not found anything specifically addressing iron deficiency! Thank you anyone who might be able to direct to a resource or offer info!
CAFs create a dense, fibrotic "wall" around tumors that excludes T-cells. Vitamin D acts to "de-activate" these fibroblasts, turning the TME from a stiff, hostile environment into a soft, accessible one.
Checkpoint Sensitization: By normalizing the stroma and reducing PD-L1/PD-L2 expression on myeloid cells, Vitamin D ensures that the Checkpoint Sensitization triggered by Ivermectin is not blocked by a physical or chemical wall of fibrosis.
However the article doesn’t mention quantitative effects IOW amount required to counteract the tumor’s “wall building” potential. Do you have the numbers, and/ or how to verify if one’s intake of vit D3 is high enough?
For general health you want to target a Vit D level of 40-60. If you have cancer you want to target a higher level of 60-100. With high dose VIt D3 you may wish to check the PTH level.. target level just above lower limit. (coimbra protocol). This will be reviewed in an upcoming post of Vit D3.
In the rural part of a 3rd world country, D3 blood concentration measurement is a no-no (waiting list in the capital city, also would require 300 miles travel, and back). The number I am looking for is the relationship between D3 intake and blood concentration. This is likely to be variable but my guess is it’s about 40 (IE to ng/ml, implying I would need at least 40k IE / day. Is there info on the relationship: intake vs concentration?
Excellent review of the role of terrain in cancer, with clear explanations of the terrain-modifying interventions that can lead to regression or removal of cancer. Why does it take a critical care expert to reveal the truth about what oncologists have been ignoring for more than half a century? Thank you for shedding light on cancer. We’ve been in the dark too long.
I have innumerable breast cancer mets to the liver that are growing bigger even with me receiving Abemiciclib and anti-hormone treatment. My team are looking at Olaparib now since I am BRCA2. Would taking tumeric be potentially harmful to my liver?
Can these be taken together? If one has been on metformin for several years for its anti-cancer effects, is it worth adding berb or unwise? Or substituting with berb as it's safer? Thoughts?
It is positively delightful to hear TRUTH on this site! Thank you, Dr. Marik for all you are doing to help so many of us that are fighting cancer. For me, it was breast cancer in 2002 and 2014, but I am concerned about those nasty, lingering cancer stem cells. By the way, I first learned about them from you, Dr. Marik … thank you!
Thank you for all this information Dr. Marik. You mention the importance of Network Synergy and Coordinated Interaction. Does this mean for example that Resveratrol and Metformin should always be taken together at the same time? Also, should the nutraceuticals and repurposed drugs that promote apoptosis be taken in the evening, so they work during the night?
I have a post on rotating coming up soon. NO you can take them all together or grouped or spaced out. As general rule however you should take metformin and berberine together. More to come.
Fully agree with the basic premise: cancer treatment is incomplete with medications alone, addressing the metabolic environment is an essential adjuvant therapy for a successful intervention.
The tumor metabolic environment is not an accident, is a purposefully designed microenvironment to favor tumor growth by impairing contact inhibition and decreasing immune response within. Is the same kind of integrative system mechanics that work through the entire body.
This all makes a lot of sense to me—especially the idea of immune cells being metabolically disadvantaged within it.
One thing it made me wonder is what determines that shift in resource allocation—why the system allows immune function to become under-fueled in the first place, rather than prioritizing it in the presence of a tumor?
I have used most of what you document in your article (my oncologist refused to prescribe metformin for me even though I showed him academic articles showing its synergy with chemo). If cancer is a metabolic disease and terrain is critical, then isn't the right nutrition at least half the story?
As a recovered cancer patient, I've done extensive research on which foods to eat and I've designed a system of nutrition to make it very easy for cancer patients or their carers to get the right nutrition, based on academic research. For example all of the foods in my system have anti cancer properties, or are at the very least neutral. It's vegan - meat and dairy free, which has been documented over and over as being the best for most cancer patients. Many believe that the keto diet is the best, but having been on that for over a year (while on chemo) I eventually discovered it's not - I read Dr Siegfried's book and everything else I could find on keto. Ultimately I came to the conclusion that while it may help glioblastomas (Dr Siegfried's specialist area), it is not right for most (it's also a very unnatural diet). Additionally, restricting or eliminating glucose is a stress on cancer for about 30 days but after that it emits signals to cause apoptosis in normal cells and picks up its new nutrition from the bloodstream.
I've also done research on which probiotic strains exert powerful effects (anti inflammation, immune modulation etc) and discovered synergistic pairings with plant exosomes (and their communication with specific probiotic strains) and turned these into 3 simple smoothie blends (I'm not yet sure if this should go into a separate book as there is a lot of research on which its based and a chapter on helping with dysbiosis). The nutrition book is almost complete. If you have any interest in reading it, pls let me know - it would take me about a week to bring it up to draft standard. it can be used with any treatment protocol. I would love to align what Ive found out with your research to make safe eating and nutrition as easy as possible for people facing this overwhelming challenge.
Thanks for your comments. I agree that nutrition is the foundation of any treatment approach.. and as you recognize one key does not fit all people. You can send me your synopsis at pmarik@protonmail.com.
Thank you, I will do that
Hello, I’m really interested in your book and research and would love to learn more about what you’ve found most helpful, particularly what has worked for you in helping you feel alive, in terms of energy, vitality, and overall wellbeing.
I’m also widely read in this area and familiar with approaches such as the ketogenic diet, as well as the work of Thomas Seyfried and Jane McLelland. I’m a cancer survivor myself, my diagnosis was a rare, slow-growing liposarcoma, which was surgically removed.
I’d be very interested to hear what has worked best for you in practice. If you’re open to sharing more, I’d be grateful if you could reach me at claudia.gasparini@alumni.griffithuni.edu.au. I’d love to hear from you. Many thanks, Claudia
I also read Jane McClellands book. Unfortunately by the time I got to the big reveal in chapter 11, I was suffering badly from chemo brain at the time and couldn’t understand any of it!
I’m happy to share what I know with anyone who’s interested. I’m not going to share here as this is Dr Marik’s platform, but while energy and vitality are difficult there are ways to improve that. Contact me directly if you want.
Thank you, I really appreciate your response.
I’d be very interested to learn from your experience, particularly what you’ve found helpful in supporting energy and vitality.
I’ve shared my email above, but if you’d prefer, I’d be happy to contact you directly, please feel free to share your preferred contact details.
Thank you again, I look forward to connecting.
I would be interested in your approach. You can e-mail me at pmarik@protonmail.com
so sorry, I missed that, sending you an email now
Thank you for sharing with Dr. Marik Your additional information on nutrition I believe it is largely my combined Dr Marik’s protocol and Supplements and Dr Makis Protocol. Dr. Marik responded to an earlier inquiry I had because my cancer is recurrent ovarian cancer which is contraindicated in some clinical papers for the ketogenic approach which he is acknowledging again here. Would be very interested if both you and Dr Marik Commented once he has reviewed your book and all of us will be very excited to hear of its completion and when it will be available. The only other Q I see that differs between the repurpose drug protocols in the Cancer care 2.0 book of Dr. Marik And the journal of ortho molecular medicine cellular cancer protocol Is seemingly great differences in the volume of mebenz/febenz. If anyone knows the answer to that it would be helpful as well. My cancer is very tricky right now and I want to make sure I am maximizing every aspect so I can get more response going since the chemo keeps failing but I am currently on one and I believe that if I could get an additional optimized confidence in Every aspect I don't know if Dr Marik Does telehealth or reviews medical treatment and repurposed and nutritional efforts on the part of the patient. God bless Dr. Marik, There is no way to overstate the sacrifices he has made to first bring the truth during the pandemic and suffer and then have his incredible illustrious career achievements in human medicine ripped away by corrupt institutions! Thank you all for this helpful conversation as we tried to stay alive with confidence and faith in God for making people like Paul!
Thanks my friend.
Totally agree, diet is essential in dealing with cancer. Was just diagnosed with cancer and trying to put a daily protocol together to transition to another form of eating. Would love to learn what has worked for you! Email: wisandmo@aol.com
I am also very interested in your book.
Ummmm I am very interested in your nutrition book!?!
Hello all. I am on Paul Marik's protocol and have been since January 23. I am stage four recurrent ovarian. I was miraculously healed the first time around when I went in for a nine hour surgery of colon resections removals and debulking and there was no cancer. Diagnosed recurrent six months later and learned of the protocol in addition to going back to chemotherapy. This chemo is a bit different although still a platinum based and I am now running into iron deficiency does anyone have familiarity with success in increasing blood iron levels without getting into more pills etc, (especially since constipation is already a problem). I had two rounds of heme iron infusions but they obviously did not last very long since it has been less than two months my recent blood work showed hemochromia. Any input welcome I have not found anything specifically addressing iron deficiency! Thank you anyone who might be able to direct to a resource or offer info!
No tumeric is fine.
CAFs create a dense, fibrotic "wall" around tumors that excludes T-cells. Vitamin D acts to "de-activate" these fibroblasts, turning the TME from a stiff, hostile environment into a soft, accessible one.
Checkpoint Sensitization: By normalizing the stroma and reducing PD-L1/PD-L2 expression on myeloid cells, Vitamin D ensures that the Checkpoint Sensitization triggered by Ivermectin is not blocked by a physical or chemical wall of fibrosis.
Looking for a reference, I found this: https://ar.iiarjournals.org/content/36/12/6225
However the article doesn’t mention quantitative effects IOW amount required to counteract the tumor’s “wall building” potential. Do you have the numbers, and/ or how to verify if one’s intake of vit D3 is high enough?
For general health you want to target a Vit D level of 40-60. If you have cancer you want to target a higher level of 60-100. With high dose VIt D3 you may wish to check the PTH level.. target level just above lower limit. (coimbra protocol). This will be reviewed in an upcoming post of Vit D3.
In the rural part of a 3rd world country, D3 blood concentration measurement is a no-no (waiting list in the capital city, also would require 300 miles travel, and back). The number I am looking for is the relationship between D3 intake and blood concentration. This is likely to be variable but my guess is it’s about 40 (IE to ng/ml, implying I would need at least 40k IE / day. Is there info on the relationship: intake vs concentration?
Excellent review of the role of terrain in cancer, with clear explanations of the terrain-modifying interventions that can lead to regression or removal of cancer. Why does it take a critical care expert to reveal the truth about what oncologists have been ignoring for more than half a century? Thank you for shedding light on cancer. We’ve been in the dark too long.
Thanks Mark very kind of you.
The most profound role of Vitamin D in a metabolic approach is its ability to inhibit Cancer-Associated Fibroblasts (CAFs).
I have innumerable breast cancer mets to the liver that are growing bigger even with me receiving Abemiciclib and anti-hormone treatment. My team are looking at Olaparib now since I am BRCA2. Would taking tumeric be potentially harmful to my liver?
My brother just got diagnosed with Chronic Lymphocytic Leukemia (CLL). Would a Repurposed drugs protocol help?
Metformin and Berberine.
Can these be taken together? If one has been on metformin for several years for its anti-cancer effects, is it worth adding berb or unwise? Or substituting with berb as it's safer? Thoughts?
It is positively delightful to hear TRUTH on this site! Thank you, Dr. Marik for all you are doing to help so many of us that are fighting cancer. For me, it was breast cancer in 2002 and 2014, but I am concerned about those nasty, lingering cancer stem cells. By the way, I first learned about them from you, Dr. Marik … thank you!
Thank you my death.. death to the cancer stem cells
Well done, Doc.
Thank you for all this information Dr. Marik. You mention the importance of Network Synergy and Coordinated Interaction. Does this mean for example that Resveratrol and Metformin should always be taken together at the same time? Also, should the nutraceuticals and repurposed drugs that promote apoptosis be taken in the evening, so they work during the night?
I have a post on rotating coming up soon. NO you can take them all together or grouped or spaced out. As general rule however you should take metformin and berberine together. More to come.
I am also interested in the metformin+ berberine together...or seperately...or instead of question! Thanks.
Fully agree with the basic premise: cancer treatment is incomplete with medications alone, addressing the metabolic environment is an essential adjuvant therapy for a successful intervention.
The tumor metabolic environment is not an accident, is a purposefully designed microenvironment to favor tumor growth by impairing contact inhibition and decreasing immune response within. Is the same kind of integrative system mechanics that work through the entire body.
— Carlos
This all makes a lot of sense to me—especially the idea of immune cells being metabolically disadvantaged within it.
One thing it made me wonder is what determines that shift in resource allocation—why the system allows immune function to become under-fueled in the first place, rather than prioritizing it in the presence of a tumor?
Good point.